Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | DNM1L | O00429 | 2/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | GNRHR | P30968 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 8/20 | 0.36 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5049183 | 0.90 | NPC1 (0.40) | CLK1KDM4EKMT2ARXFP1RAB9A | |
| SCHEMBL5039478 | 0.89 | CLK1 (0.45) | CLK1KDM4EKMT2ARXFP1RAB9A | |
| SCHEMBL5044496 | 0.88 | ATP4A (0.37) | MAPT | |
| SCHEMBL5047889 | 0.87 | MGLL (0.36) | KMT2ARXFP1RAB9ANPC1MAPT | |
| SCHEMBL5044102 | 0.86 | MAPT (0.40) | KDM4ERAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5040330 | 0.86 | NTMT1 (0.40) | RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL5048696 | 0.86 | CDC25A (0.43) | KDM4EKMT2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL5039575 | 0.84 | AR (0.43) | KMT2ARAB9AALDH1A1MAPT | |
| SCHEMBL5044042 | 0.84 | CDC25A (0.42) | KDM4EKMT2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL5047653 | 0.84 | ATP4A (0.38) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583762-B1 | PYRROLYL-THIAZOLES AND THEIR USE AS CB 1 RECEPTOR INVERSE AGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-09 | — | — | EP | claimed |