Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 8/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CPT2 | P23786 | 1/20 | 0.35 |
| ▸ | CPT1A | P50416 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5043754 | 0.90 | CLK1 (0.45) | NPC1RAB9AALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL5044496 | 0.89 | ATP4A (0.37) | LMNAMAPT | |
| SCHEMBL5047889 | 0.88 | MGLL (0.36) | NPC1RAB9ALMNAKMT2AMEN1 | |
| SCHEMBL4425161 | 0.88 | RAB9A (0.43) | NPC1RAB9AHPGDALDH1A1MAPK1 | |
| SCHEMBL5039387 | 0.88 | NPC1 (0.47) | NPC1RAB9ATGFBR1HPGDALDH1A1 | |
| SCHEMBL5044102 | 0.88 | MAPT (0.40) | NPC1RAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL5040330 | 0.88 | NTMT1 (0.40) | NPC1RAB9ALMNASMN1; SMN2CPT1A | |
| SCHEMBL5048696 | 0.87 | CDC25A (0.43) | NPC1RAB9AHPGDALDH1A1KCNQ1 | |
| SCHEMBL5039575 | 0.85 | AR (0.43) | RAB9AALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL5044042 | 0.85 | CDC25A (0.42) | NPC1RAB9AALDH1A1KCNQ1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583762-B1 | PYRROLYL-THIAZOLES AND THEIR USE AS CB 1 RECEPTOR INVERSE AGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-09 | — | — | EP | claimed |