Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.47 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.47 |
| ▸ | ABAT | P80404 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.46 |
| ▸ | TUBB | P07437 | 4/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.46 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.46 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.46 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.46 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.46 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.46 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16619850 | 0.87 | ALDH1A1 (0.59) | ALDH1A1TSHRTUBB1HPGDTRIM24 | |
| SCHEMBL96635 | 0.87 | ALDH1A1 (0.59) | ALDH1A1TSHRTUBB1HPGDTRIM24 | |
| SCHEMBL470698 | 0.87 | SRC (0.57) | ALDH1A1TSHRTUBB1SRCHPGD | |
| Hydrochloric Acid SCHEMBL23711567 | 0.85 | ALDH1A1 (0.57) | ALDH1A1TSHRTUBB1HPGDTRIM24 | |
| SCHEMBL13116218 | 0.83 | SRC (0.42) | ALDH1A1TSHRTUBB1SRCHPGD | |
| SCHEMBL13573079 | 0.83 | ALDH1A1 (0.46) | ALDH1A1TSHRTUBB1SRCHPGD | |
| SCHEMBL24110815 | 0.83 | TUBB4A (0.52) | ALDH1A1TSHRTUBB1SRCHPGD | |
| SCHEMBL20376313 | 0.82 | TUBB1 (0.54) | ALDH1A1TUBB1HPGDTUBB4ATUBB | |
| SCHEMBL111326 | 0.82 | ALDH1A1 (0.53) | ALDH1A1TSHRTUBB1SRCHPGD | |
| SCHEMBL17655658 | 0.82 | ALDH1A1 (0.53) | ALDH1A1TSHRTUBB1HPGDTRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794620-B1 | BODIPY STRUCTURE FLUORESCENCE PROBES FOR DIVERSE BIOLOGICAL APPLICATIONS | NAT UNIV SINGAPORE (SG) | 2017-11-15 | — | — | EP | disclosed |
| US-20130131018-A1 | SUBSTITUTED ISOQUINOLINES AND THEIR USE AS TUBULIN POLYMERIZATION INHIBITORS | EXONHIT S.A. (FR) | 2013-05-23 | — | — | US | disclosed |
| WO-2013016441-A1 | HIV INTEGRASE INHIBITORY OXOISOINDOLINE SULFONAMIDES | The United States of America, represented by The Secretary, Department of Health & Human Services (US) | 2013-01-31 | — | — | WO | disclosed |
| WO-2012062905-A2 | CHROMENE DERIVATIVES AND THEIR ANALOGA AS WNT PATHWAY ANTAGONISTS | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ) (DE) | 2012-05-18 | — | — | WO | disclosed |
| WO-2012062901-A2 | CHROMENE DERIVATIVES AND THEIR ANALOGA AS WNT PATHWAY ANTAGONISTS | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ) (DE) | 2012-05-18 | — | — | WO | disclosed |
| US-20120028920-A1 | DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZO[B]THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. | 2012-02-02 | — | — | US | disclosed |
| US-7507851-B2 | Halocombstatins and methods of synthesis thereof | ARIZONA BOARD OF REGENTS, A STATE CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2009-03-24 | — | — | US | disclosed |
| US-20080119649-A1 | HALOCOMBSTATINS AND METHODS OF SYNTHESIS THEREOF | ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY | 2008-05-22 | — | — | US | disclosed |
| CN-1105117-C | Pharmaceutical aminophosphonic acid derivatives | SYMPHAR SA (CH) | 2003-04-09 | — | — | CN | disclosed |
| US-20020082423-A1 | Pharmaceutical aminophosphonic acid derivatives | SMITHKLINE BEECHAM P.L.C. AND SYMPHAR | 2002-06-27 | — | — | US | disclosed |
| US-6303784-B1 | AMINOPHOSPHONATES ALPHA SUBSTITUTED BY PHENOL GROUPS HAVE LIPOPROTEIN LOWERING ACTIVITY. | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-10-16 | — | — | US | disclosed |
| CN-1240451-A | Pharmaceutical aminophosphonic acid derivatives | SYMPHAR SA (CH) | 2000-01-05 | — | — | CN | disclosed |
| EP-0946572-A1 | PHARMACEUTICAL AMINOPHOSPHONIC ACID DERIVATIVES | SYMPHAR S.A. (CH) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998028310-A1 | PHARMACEUTICAL AMINOPHOSPHONIC ACID DERIVATIVES | SYMPHAR S.A. (CH) | 1998-07-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020082423-A1 | Pharmaceutical aminophosphonic acid derivatives | APOB, LIPA, PHOSPHO1 | ALDH1A1 969/4885TSHR 3015/4885TUBB1 1799/4885 |
| US-20080119649-A1 | HALOCOMBSTATINS AND METHODS OF SYNTHESIS THEREOF | TUBB3, TUBB8B, TUBB8 | ALDH1A1 4790/4885TSHR 3150/4885TUBB1 8/4885 |
| US-20120028920-A1 | DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZO[B]THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS | GRIN2C, GRIN2B, PMP22 | ALDH1A1 408/4885TSHR 168/4885TUBB1 384/4885 |
| US-20130131018-A1 | SUBSTITUTED ISOQUINOLINES AND THEIR USE AS TUBULIN POLYMERIZATION INHIBITORS | TUBB3, TUBB, TUBB1 | ALDH1A1 2257/4885TSHR 4849/4885TUBB1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.