Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3228082 | 0.82 | THRB (0.32) | LMNATHRB | |
| SCHEMBL12272261 | 0.82 | SOAT1 (0.32) | LMNATHRB | |
| SCHEMBL4132648 | 0.78 | ALDH1A1 (0.37) | LMNAALDH1A1HSD17B10 | |
| SCHEMBL12271661 | 0.78 | LMNA (0.33) | LMNA | |
| SCHEMBL5503239 | 0.78 | MGAM (0.30) | — | |
| SCHEMBL12272631 | 0.77 | — | — | |
| SCHEMBL5045856 | 0.75 | ACACB (0.31) | — | |
| SCHEMBL5049024 | 0.74 | ACACB (0.30) | — | |
| SCHEMBL25191781 | 0.71 | ALDH1A1 (0.33) | ALDH1A1HSD17B10 | |
| Urea SCHEMBL28099831 | 0.71 | ALOX15 (0.36) | THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404859-B2 | Thiazole and thiophene compounds | HOFFMANN-LA ROCHE INC. (US) | 2013-03-26 | — | — | US | disclosed |
| US-8404859-B2 | Thiazole and thiophene compounds | HOFFMANN-LA ROCHE INC. (US) | 2013-03-26 | — | — | US | disclosed |
| US-8404859-B2 | Thiazole and thiophene compounds | HOFFMANN-LA ROCHE INC. (US) | 2013-03-26 | — | — | US | disclosed |
| US-20120238569-A1 | THIAZOLE AND THIOPHENE COMPOUNDS | GILLESPIE PAUL (US) | 2012-09-20 | — | — | US | disclosed |
| WO-2012123471-A1 | THIAZOLE AND THIOPHENE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-09-20 | — | — | WO | disclosed |
| US-20120238569-A1 | THIAZOLE AND THIOPHENE COMPOUNDS | GILLESPIE PAUL (US) | 2012-09-20 | — | — | US | disclosed |
| US-20120238569-A1 | THIAZOLE AND THIOPHENE COMPOUNDS | GILLESPIE PAUL (US) | 2012-09-20 | — | — | US | disclosed |
| US-7351700-B2 | Aminomethylpyrimidines as allosteric enhancers of the GABAB receptors | HOFFMANN-LA ROCHE INC. (US) | 2008-04-01 | — | — | US | disclosed |
| EP-1725239-B1 | 4-(SULFANYL-PYRIMIDIN-4-YLMETHYL)-MORPHOLINE DERIVATIVES AND RELATED COMPOUNDS AS GABA RECEPTOR LIGANDS FOR THE TREATMENT OF ANXIETY, DEPRESSION AND EPILEPSY | HOFFMANN LA ROCHE (CH) | 2007-07-18 | — | — | EP | disclosed |
| EP-1725239-A1 | 4-(SULFANYL-PYRIMIDIN-4-YLMETHYL)-MORPHOLINE DERIVATIVES AND RELATED COMPOUNDS AS GABA RECEPTOR LIGANDS FOR THE TREATMENT OF ANXIETY, DEPRESSION AND EPILEPSY | F.HOFFMANN-LA ROCHE AG (CH) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005094828-A1 | 4- (SULFANYL-PYRIMIDIN-4-YLMETHYL) -MORPHOLINE DERIVATIVES AND RELATED COMPOUNDS AS GABA RECEPTOR LIGANDS FOR THE TREATMENT OF ANXIETY, DEPRESSION AND EPILEPSY | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-13 | — | — | WO | disclosed |
| US-20050197337-A1 | Aminomethylpyrimidines as allosteric enhancers of the GABAB receptors | HOFFMANN-LA ROCHE INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197337-A1 | Aminomethylpyrimidines as allosteric enhancers of the GABAB receptors | CHRNA2, CNR2, GABRB2 | LMNA 4113/4885ALDH1A1 3230/4885HSD17B10 4357/4885 |
| US-20120238569-A1 | THIAZOLE AND THIOPHENE COMPOUNDS | TSLP, CFTR, TPMT | LMNA 4731/4885ALDH1A1 295/4885HSD17B10 845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.