Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5048336 | 0.85 | NAAA (0.41) | PTGS2NAAADRD2DRD4DRD3 | |
| SCHEMBL6022121 | 0.83 | GPR139 (0.43) | PTGS2NAAAHDAC1HDAC2LMNA | |
| SCHEMBL6022152 | 0.76 | DRD2 (0.43) | NAAADRD2DRD4DRD3ASAH1 | |
| SCHEMBL6022126 | 0.76 | ALDH1A1 (0.46) | NAAAHDAC1HDAC2LMNASMN1; SMN2 | |
| SCHEMBL1854176 | 0.76 | NAAA (0.40) | NAAADRD2DRD4DRD3HDAC1 | |
| SCHEMBL5043892 | 0.75 | GLI1 (0.43) | HDAC1HDAC2NPC1RAB9AHIF1A | |
| SCHEMBL6022090 | 0.75 | GLI1 (0.43) | HDAC1HDAC2NPC1RAB9AHIF1A | |
| SCHEMBL5047944 | 0.73 | DRD2 (0.46) | PTGS2NAAADRD2DRD4DRD3 | |
| SCHEMBL5047162 | 0.73 | HDAC1 (0.44) | PTGS2NAAADRD2DRD4DRD3 | |
| SCHEMBL5039660 | 0.73 | HDAC1 (0.44) | PTGS2NAAADRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | disclosed |