Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.67 |
| ▸ | HPGD | P15428 | 6/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.67 |
| ▸ | GAA | P10253 | 4/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.67 |
| ▸ | GLA | P06280 | 2/20 | 0.67 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | MAOB | P27338 | 7/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | CA12 | O43570 | 4/20 | 0.58 |
| ▸ | CA2 | P00918 | 4/20 | 0.58 |
| ▸ | CA4 | P22748 | 4/20 | 0.58 |
| ▸ | CA7 | P43166 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | CA3 | P07451 | 1/20 | 0.58 |
| ▸ | CA6 | P23280 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1415893 | 0.84 | NPC1 (0.69) | ALDH1A1HPGDKDM4EGAAHSD17B10 | |
| SCHEMBL19338224 | 0.80 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4EGAAHSD17B10 | |
| SCHEMBL1366531 | 0.79 | CYP2C19 (0.78) | ALDH1A1HPGDKDM4EGAAHSD17B10 | |
| SCHEMBL203997 | 0.79 | SLC16A3 (1.00) | ALDH1A1HPGDKDM4EGAAHSD17B10 | |
| SCHEMBL4347045 | 0.78 | ALDH1A1 (0.64) | ALDH1A1HPGDKDM4EGAAHSD17B10 | |
| SCHEMBL4346169 | 0.78 | ALDH1A1 (0.64) | ALDH1A1HPGDKDM4EGAAHSD17B10 | |
| SCHEMBL4346162 | 0.78 | ALDH1A1 (0.64) | ALDH1A1HPGDKDM4EGAAHSD17B10 | |
| SCHEMBL1406743 | 0.78 | ALDH1A1 (0.67) | ALDH1A1HPGDKDM4EGAAHSD17B10 | |
| SCHEMBL6687148 | 0.78 | MAOB (0.76) | ALDH1A1HPGDKDM4EGAAHSD17B10 | |
| SCHEMBL52650 | 0.77 | ALDH1A1 (0.81) | ALDH1A1HPGDKDM4EGAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295053-B1 | Novel 2H-chromen-2-one-3-carboxamides for medical uses | INST MATERIA MEDICA CAMS (CN) | 2016-10-19 | — | — | EP | disclosed |
| US-8338401-B2 | Coumarin-amide derivatives and its preparation, said drug composition and its use | INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2012-12-25 | — | — | US | disclosed |
| WO-2008013928-A2 | TREATMENT OF CANCER WITH INTERFERON GENE DELIVERY IN COMBINATION WITH A TGF-BETA INHIBITOR | BIOGEN IDEC MA INC. (US) | 2008-01-31 | — | — | WO | disclosed |
| US-20060148834-A1 | Novel coumarin-amide derivatives and its preparation, said drug composition and its use | INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2006-07-06 | — | — | US | disclosed |
| EP-1570846-A1 | THE NOVEL COUMARIN-AMIDE DERIVATIVES AND ITS PREPARATION, SAID DRUG COMPOSITION AND ITS USE | THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2005-09-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148834-A1 | Novel coumarin-amide derivatives and its preparation, said drug composition and its use | INSR, GLS, INSRR | ALDH1A1 1795/4885HPGD 858/4885KDM4E 2436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.