Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
| ▸ | ILK | Q13418 | 1/20 | 0.35 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5596244 | 0.90 | CDK1 (0.43) | PTGS1PTGS2MAPK8MAPK9MAPK10 | |
| SCHEMBL5138885 | 0.89 | CSNK1D (0.41) | MAPK8MAPK9MAPK10NPC1RAB9A | |
| SCHEMBL5110395 | 0.86 | ALDH1A1 (0.46) | MAPK8MAPK9MAPK10NPC1RAB9A | |
| SCHEMBL17709604 | 0.85 | MAPK10 (0.56) | MAPK8MAPK9MAPK10IRAK4NPC1 | |
| SCHEMBL5103181 | 0.84 | ALDH1A1 (0.43) | MAPK8MAPK9MAPK10NPC1RAB9A | |
| SCHEMBL5096401 | 0.84 | ILK (0.48) | MAPK8MAPK9MAPK10IRAK4NPC1 | |
| SCHEMBL5103578 | 0.82 | SMN1; SMN2 (0.46) | IRAK4NPC1RAB9ACDK1KDR | |
| SCHEMBL5596497 | 0.82 | KDM4E (0.42) | MAPK9MAPK10IRAK4NPC1RAB9A | |
| SCHEMBL5597099 | 0.78 | PTGS1 (0.46) | PTGS1PTGS2MAPK8MAPK9MAPK10 | |
| SCHEMBL5596747 | 0.77 | CDK1 (0.35) | MAPK8MAPK9MAPK10IRAK4CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470686-B2 | Method of inhibiting the expression and/or the activity of JNK | LABORATOIRES SERONO SA (CH) | 2008-12-30 | — | — | US | claimed |