Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5110395 | 0.89 | ALDH1A1 (0.46) | MAPK8MAPK9MAPK10MAPTALDH1A1 | |
| SCHEMBL5100115 | 0.89 | PTGS1 (0.41) | MAPK8MAPK9MAPK10MAPTLMNA | |
| SCHEMBL17709604 | 0.85 | MAPK10 (0.56) | MAPK8MAPK9MAPK10ALDH1A1CYP3A4 | |
| SCHEMBL5096401 | 0.84 | ILK (0.48) | MAPK8MAPK9MAPK10MAPTALDH1A1 | |
| SCHEMBL5103181 | 0.84 | ALDH1A1 (0.43) | MAPK8MAPK9MAPK10MAPTALDH1A1 | |
| SCHEMBL5596244 | 0.84 | CDK1 (0.43) | MAPK8MAPK9MAPK10MAPTALDH1A1 | |
| SCHEMBL5103578 | 0.82 | SMN1; SMN2 (0.46) | MAPTALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5596497 | 0.82 | KDM4E (0.42) | MAPK9MAPK10MAPTALDH1A1RAB9A | |
| SCHEMBL5596896 | 0.78 | CSNK1D (0.45) | CSNK1DHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL5596747 | 0.77 | CDK1 (0.35) | MAPK8MAPK9MAPK10MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470686-B2 | Method of inhibiting the expression and/or the activity of JNK | LABORATOIRES SERONO SA (CH) | 2008-12-30 | — | — | US | claimed |