Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5596244 | 0.91 | CDK1 (0.43) | ALDH1A1NPC1RAB9AMAPTKDM4E | |
| SCHEMBL5096401 | 0.91 | ILK (0.48) | ALDH1A1NPC1RAB9AMAPTKDM4E | |
| SCHEMBL5103578 | 0.90 | SMN1; SMN2 (0.46) | ALDH1A1NPC1RAB9AMAPTKDM4E | |
| SCHEMBL5110395 | 0.86 | ALDH1A1 (0.46) | ALDH1A1NPC1RAB9AMAPTKDM4E | |
| SCHEMBL5596497 | 0.86 | KDM4E (0.42) | ALDH1A1NPC1RAB9AMAPTKDM4E | |
| SCHEMBL17709604 | 0.86 | MAPK10 (0.56) | ALDH1A1NPC1RAB9AKDM4EHPGD | |
| SCHEMBL5138885 | 0.84 | CSNK1D (0.41) | ALDH1A1NPC1RAB9AMAPTKDM4E | |
| SCHEMBL5100115 | 0.84 | PTGS1 (0.41) | NPC1RAB9AMAPTLMNACDK1 | |
| SCHEMBL5596747 | 0.79 | CDK1 (0.35) | ALDH1A1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL5103679 | 0.78 | IRAK4 (0.46) | POLBKDRMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470686-B2 | Method of inhibiting the expression and/or the activity of JNK | LABORATOIRES SERONO SA (CH) | 2008-12-30 | — | — | US | claimed |
| EP-1696909-B1 | BENZOTHIAZOLE DERIVATIVES FOR THE TREATMENT OF DIABETES | SERONO LAB (CH) | 2007-11-14 | — | — | EP | claimed |