Sugi Predict

Sugi Predict / Compounds / SCHEMBL511746

SCHEMBL511746

SCHEMBL511746

C=CB(O)Oc1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA1 P00915 2/20 0.39
▸ CA2 P00918 1/20 0.39
▸ LTA4H P09960 2/20 0.36
▸ TSHR P16473 2/20 0.36
▸ THRB P10828 1/20 0.35
▸ CA5A P35218 2/20 0.34
▸ CA5B Q9Y2D0 2/20 0.34
▸ TGM2 P21980 1/20 0.34
▸ CA4 P22748 2/20 0.33
▸ ALDH1A1 P00352 2/20 0.33
▸ CA6 P23280 1/20 0.33
▸ CA7 P43166 1/20 0.33
▸ ENPP2 Q13822 1/20 0.33
▸ CA14 Q9ULX7 1/20 0.33
▸ NR1H2 P55055 1/20 0.33
▸ BAX Q07812 1/20 0.33
▸ PCSK9 Q8NBP7 1/20 0.33
▸ ORAI1 Q96D31 1/20 0.33
▸ ORAI2 Q96SN7 1/20 0.33
▸ ORAI3 Q9BRQ5 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3196690 0.88 CA1 (0.31) CA1CA2ENPP2
SCHEMBL3196704 0.79 ENPP2 (0.37) CA1CA2TSHRCA4ALDH1A1
SCHEMBL28956769 0.78 ACHE (0.39) CA1CA2TSHRTGM2ALDH1A1
SCHEMBL1661656 0.76 LTA4H (0.39) CA1CA2LTA4HTSHRTHRB
SCHEMBL28109978 0.76 CA1 (0.38) CA1CA2LTA4HTSHRTHRB
SCHEMBL3395239 0.74 CA1 (0.36) CA1CA2LTA4HTSHRTHRB
Ethylene SCHEMBL50747 0.73 CA1 (0.43) CA1CA2LTA4HTSHRCA5A
SCHEMBL403639 0.72 CA2 (0.43) CA1CA2TSHRCA5ACA5B
SCHEMBL28337059 0.72 CA1 (0.46) CA1CA2LTA4HTSHRCA5A
SCHEMBL78440 0.72 CA1 (0.46) CA1CA2LTA4HTSHRCA5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11602724-B2 Visible light induced photogeneration of ground state atomic oxygen SAINT LOUIS UNIVERSITY (US) 2023-03-14 — — US disclosed
US-20200346183-A1 VISIBLE LIGHT INDUCED PHOTOGENERATION OF GROUND STATE ATOMIC OXYGEN SAINT LOUIS UNIVERSITY (US) 2020-11-05 — — US disclosed
CN-109265475-A A kind of preparation method of polysubstituted aryl ethylene pinacol borate derivative 清华大学 2019-01-25 — — CN disclosed
EP-2571843-B1 IMPROVED PREPARATION OF CHALCONE DERIVATIVES GENFIT (FR) 2017-12-27 — — EP disclosed
EP-2668168-B1 COMPOUNDS FOR THE REDUCTION OF ß-AMYLOID PRODUCTION BRISTOL MYERS SQUIBB CO (US) 2017-03-01 — — EP disclosed
US-20150336975-A1 COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION BRISTOL-MYERS SQUIBB COMPANY (US) 2015-11-26 — — US disclosed
EP-2459197-B1 COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION BRISTOL MYERS SQUIBB CO (US) 2015-10-14 — — EP disclosed
US-20150152089-A1 COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION BRISTOL MYERS SQUIBB CO (US) 2015-06-04 — — US disclosed
US-8765992-B2 Preparation of chalcone derivatives GENFIT (FR) 2014-07-01 — — US disclosed
US-8710061-B2 Compounds for the reduction of β-amyloid production BRISTOL-MYERS SQUIBB COMPANY (US) 2014-04-29 — — US disclosed
EP-2571843-A1 IMPROVED PREPARATION OF CHALCONE DERIVATIVES Genfit (FR) 2013-03-27 — — EP disclosed
US-20130030011-A1 COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION BRISTOL-MYERS SQUIBB COMPANY 2013-01-31 — — US disclosed
WO-2012103297-A1 COMPOUNDS FOR THE REDUCTION OF β-AMYLOID PRODUCTION BRISTOL-MYERS SQUIBB COMPANY (US) 2012-08-02 — — WO disclosed
EP-2459197-A1 COMPOUNDS FOR THE REDUCTION OF -AMYLOID PRODUCTION Bristol-Myers Squibb Company (US) 2012-06-06 — — EP disclosed
US-20120028994-A1 COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION BRISTOL-MYERS SQUIBB COMPANY 2012-02-02 — — US disclosed
WO-2011144579-A1 IMPROVED PREPARATION OF CHALCONE DERIVATIVES GENFIT (FR) 2011-11-24 — — WO disclosed
US-20110212937-A1 COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION BRISTOL-MYERS SQUIBB COMPANY 2011-09-01 — — US disclosed
WO-2011014535-A1 COMPOUNDS FOR THE REDUCTION OF β-AMYLOID PRODUCTION BRISTOL-MYERS SQUIBB COMPANY (US) 2011-02-03 — — WO disclosed
EP-2069333-A1 PYRROLE DERIVATIVES USEFUL FOR THE TREATMENT OF CYTOKINE-MEDIATED DISEASES Novartis Ag (CH) 2009-06-17 — — EP disclosed
WO-2008034600-A1 PYRROLE DERIVATIVES USEFUL FOR THE TREATMENT OF CYTOKINE-MEDIATED DISEASES NOVARTIS AG (CH) 2008-03-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110212937-A1 COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION APP, BACE1, IAPP CA1 749/4885CA2 2471/4885LTA4H 1848/4885
US-20150152089-A1 COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION APP, BACE1, IAPP CA1 749/4885CA2 2471/4885LTA4H 1848/4885
US-20200346183-A1 VISIBLE LIGHT INDUCED PHOTOGENERATION OF GROUND STATE ATOMIC OXYGEN PPOX, SOD1, NFE2L2 CA1 1977/4885CA2 1257/4885LTA4H 1991/4885
US-20120028994-A1 COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION APP, BACE1, IAPP CA1 749/4885CA2 2471/4885LTA4H 1848/4885
US-11602724-B2 Visible light induced photogeneration of ground state atomic oxygen PPOX, SOD1, NFE2L2 CA1 1977/4885CA2 1257/4885LTA4H 1991/4885
US-20150336975-A1 COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION APP, BACE1, IAPP CA1 749/4885CA2 2471/4885LTA4H 1848/4885
US-20130030011-A1 COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION APP, BACE1, IAPP CA1 749/4885CA2 2471/4885LTA4H 1848/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.