SCHEMBL5143591

SCHEMBL5143591

C=Cc1ccccc1COC(=O)c1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 1/20 0.56
TDP1 Q9NUW8 3/20 0.54
KMT2A Q03164 3/20 0.54
SLC6A2 P23975 1/20 0.54
SLC6A3 Q01959 1/20 0.54
ALDH1A1 P00352 3/20 0.49
LMNA P02545 4/20 0.46
MAPK1 P28482 2/20 0.46
HIF1A Q16665 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
L3MBTL1 Q9Y468 2/20 0.44
TSHR P16473 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
MAPT P10636 3/20 0.42
RAB9A P51151 2/20 0.42
POLB P06746 1/20 0.42
PKM P14618 1/20 0.42
F2 P00734 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8385271 0.91 LMNA (0.55) PPARGTDP1KMT2ASLC6A2SLC6A3
SCHEMBL10943977 0.86 CA12 (0.46) PPARGTDP1KMT2ASLC6A2SLC6A3
SCHEMBL8164190 0.86 L3MBTL1 (0.65) PPARGTDP1KMT2ASLC6A2SLC6A3
SCHEMBL878376 0.85 PPARG (0.58) PPARGTDP1KMT2ASLC6A2SLC6A3
SCHEMBL27981237 0.84 TDP1 (0.53) PPARGTDP1KMT2ASLC6A2SLC6A3
SCHEMBL10719292 0.84 TYR (0.55) L3MBTL1
SCHEMBL5085480 0.82 PPARG (0.71) PPARGTDP1KMT2ASLC6A2SLC6A3
SCHEMBL22619968 0.81 PPARG (0.42) PPARGTDP1KMT2ASLC6A2SLC6A3
SCHEMBL11545205 0.81 L3MBTL1 (0.48) PPARGTDP1KMT2AALDH1A1LMNA
SCHEMBL1415640 0.80 L3MBTL1 (0.52) PPARGTDP1KMT2ASLC6A2SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5589312-A RESIN GRAINS FUJI PHOTO FILM CO., LTD. (JP) 1996-12-31 US claimed
CN-104812790-B Organopolysiloxane graft polymers 花王株式会社 2019-04-12 CN disclosed
EP-2927253-B1 ORGANOPOLYSILOXANE GRAFT POLYMER KAO CORP (JP) 2018-09-12 EP disclosed
US-9351920-B2 Organopolysiloxane graft polymer KAO CORPORATION (JP) 2016-05-31 US disclosed
US-20150297498-A1 ORGANOPOLYSILOXANE GRAFT POLYMER KAO CORPORATION (JP) 2015-10-22 US disclosed
EP-2927253-A1 ORGANOPOLYSILOXANE GRAFT POLYMER Kao Corporation (JP) 2015-10-07 EP disclosed
CN-104812790-A Organopolysiloxane graft polymer KAO CORP 2015-07-29 CN disclosed
US-7220529-B2 Photopolymerizable composition and recording material using the same FUJIFILM CORPORATION (JP) 2007-05-22 US disclosed
US-20050186504-A1 Photopolymerizable composition and recording material using the same FUJI PHOTO FILM CO., LTD. 2005-08-25 US disclosed
EP-0910351-A1 PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS G.D. Searle & Co. (US) 1999-04-28 EP disclosed
EP-0907666-A1 PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS G.D. Searle & Co. (US) 1999-04-14 EP disclosed
WO-1997049736-A2 PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS G.D. SEARLE AND CO. (US) 1997-12-31 WO disclosed
WO-1997049387-A1 PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS G.D. SEARLE AND CO. (US) 1997-12-31 WO disclosed
US-5589312-A RESIN GRAINS FUJI PHOTO FILM CO., LTD. (JP) 1996-12-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150297498-A1 ORGANOPOLYSILOXANE GRAFT POLYMER IDUA, PIGS, GMNN PPARG 1850/4885TDP1 2793/4885KMT2A 3488/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.