Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 2/20 | 0.38 |
| ▸ | KDM5A | P29375 | 2/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7559121 | 0.83 | MAPT (0.42) | ALDH1A1MAPTKDM4AKDM5AKDM5B | |
| SCHEMBL8583458 | 0.74 | IDO1 (0.53) | — | |
| SCHEMBL8581170 | 0.73 | AKR1C3 (0.46) | MAPTKDM4EPTPN1CYP3A4PTGS1 | |
| SCHEMBL5162931 | 0.72 | FFAR4 (0.37) | CYP3A4 | |
| SCHEMBL252910 | 0.72 | PTGS2 (0.52) | ALDH1A1MAPTL3MBTL1DYRK1ACA2 | |
| SCHEMBL28348142 | 0.72 | CA2 (0.57) | ALDH1A1MAPTCA2KDM4EATM | |
| SCHEMBL7668780 | 0.71 | ALDH1A1 (0.47) | ALDH1A1MAPTKDM4AKDM5AKDM5B | |
| SCHEMBL7361993 | 0.71 | SMN1; SMN2 (0.56) | ALDH1A1MAPTMRGPRX4CA2KDM4E | |
| SCHEMBL7368290 | 0.71 | CA2 (0.45) | ALDH1A1MAPTL3MBTL1ACACBDYRK1A | |
| SCHEMBL13791120 | 0.70 | MAPT (0.39) | ALDH1A1MAPTKDM4AKDM5AKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180299456-A1 | In Situ Chemiluminescent Substrates and Assays | Life Technologies Corporation | 2018-10-18 | — | — | US | disclosed |
| US-10031142-B2 | In situ chemiluminescent substrates and assays | Life Technologies Corporation (US) | 2018-07-24 | — | — | US | disclosed |
| EP-2590958-B1 | IN SITU CHEMILUMINESCENT SUBSTRATES AND ASSAYS | LIFE TECHNOLOGIES CORP (US) | 2015-08-26 | — | — | EP | disclosed |
| US-20130196325-A1 | In Situ Chemiluminescent Substrates and Assays | Life Technologies Corporation (US) | 2013-08-01 | — | — | US | disclosed |
| EP-1120423-B1 | Improved chemiluminescent 1,2-dioxetanes | APPLERA CORP (US) | 2007-03-14 | — | — | EP | disclosed |
| EP-0649417-B1 | IMPROVED CHEMILUMINESCENT 1,2-DIOXETANES | TROPIX INC (US) | 2001-09-19 | — | — | EP | disclosed |
| EP-1120423-A1 | Improved chemiluminescent 1,2-dioxetanes | TROPIX, INC. (US) | 2001-08-01 | — | — | EP | disclosed |
| EP-1120422-A1 | Improved chemiluminescent 1,2-dioxetanes | TROPIX, INC. (US) | 2001-08-01 | — | — | EP | disclosed |
| US-5840919-A | SPIROADAMANTYL 1,2-DIOXETANES CHARACTERIZED BY SUBSTITUENT ON AROMATIC RING IN ADDITION TO META-SUBSTITUTED ENZYME-LABILE GROUP | TROPIX, INC. (US) | 1998-11-24 | — | — | US | disclosed |
| US-5582980-A | Chemiluminescent 1,2-dioxetanes | TROPIX, INC. (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0649417-A1 | IMPROVED CHEMILUMINESCENT 1,2-DIOXETANES | TROPIX, INC. (US) | 1995-04-26 | — | — | EP | disclosed |
| EP-0649417-A4 | IMPROVED CHEMILUMINESCENT 1,2-DIOXETANES. | TROPIX INC (US) | 1995-02-27 | — | — | EP | disclosed |
| WO-1994026726-A1 | IMPROVED CHEMILUMINESCENT 1,2-DIOXETANES | TROPIX, INC. (US) | 1994-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180299456-A1 | In Situ Chemiluminescent Substrates and Assays | DNASE1L3, DCLRE1B, RNASE1 | ALDH1A1 652/4885MAPT 4533/4885KDM4A 3953/4885 |
| US-10031142-B2 | In situ chemiluminescent substrates and assays | DNASE1L3, DCLRE1B, RNASE1 | ALDH1A1 652/4885MAPT 4533/4885KDM4A 3953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.