Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 known ✓ | O43570 | 1/20 | 0.62 |
| ▸ | CA1 known ✓ | P00915 | 1/20 | 0.62 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.62 |
| ▸ | CA4 known ✓ | P22748 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.88 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.88 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.64 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | CA6 | P23280 | 1/20 | 0.62 |
| ▸ | CA7 | P43166 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | CA9 | Q16790 | 1/20 | 0.62 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | NR4A1 | P22736 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phthalic Acid SCHEMBL4584474 | 0.97 | ALDH1A1 (0.82) | ALDH1A1ALOX15AKR1C3NAPRTKDM4E | |
| Phthalic Acid SCHEMBL4584478 | 0.97 | ALDH1A1 (0.82) | ALDH1A1ALOX15AKR1C3NAPRTKDM4E | |
| Phthalic Acid SCHEMBL4168570 | 0.94 | ALDH1A1 (0.78) | ALDH1A1ALOX15AKR1C3NAPRTKDM4E | |
| Phthalic Acid SCHEMBL28258532 | 0.94 | ALDH1A1 (0.88) | ALDH1A1ALOX15AKR1C3NAPRTKDM4E | |
| Phthalic Acid SCHEMBL589206 | 0.94 | ALDH1A1 (0.88) | ALDH1A1ALOX15AKR1C3NAPRTKDM4E | |
| Phthalic Acid SCHEMBL195822 | 0.94 | ALDH1A1 (0.88) | ALDH1A1ALOX15AKR1C3NAPRTKDM4E | |
| Phthalic Acid SCHEMBL5668586 | 0.94 | ALDH1A1 (1.00) | ALDH1A1ALOX15AKR1C3NAPRTKDM4E | |
| Phthalic Acid SCHEMBL10477086 | 0.94 | ALDH1A1 (1.00) | ALDH1A1ALOX15AKR1C3NAPRTKDM4E | |
| Phthalic Acid SCHEMBL1332278 | 0.94 | ALDH1A1 (1.00) | ALDH1A1ALOX15AKR1C3NAPRTKDM4E | |
| Phthalic Acid SCHEMBL146125 | 0.94 | ALDH1A1 (1.00) | ALDH1A1ALOX15AKR1C3NAPRTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111019933-A | Immobilized laccase, preparation method and application in antibiotic degradation | 天津大学 | 2020-04-17 | — | — | CN | claimed |
| US-5104794-A | Deconjugation of conjugated bilirubins to be measured using high performance liquid chromatography | UNITIKA LTD. (JP) | 1992-04-14 | — | — | US | claimed |
| US-20230414617-A1 | PHARMACEUTICAL COMPOSITION COMPRISING ACID-BASE NEUTRALIZATION COMBINATION AND APPLICATION THEREOF | CHENGDU KUACHANGAOPU MEDICAL TECH CO LTD (CN) | 2023-12-28 | — | — | US | disclosed |
| EP-4223313-A1 | PHARMACEUTICAL COMPOSITION COMPRISING ACID-BASE NEUTRALIZATION COMBINATION AND APPLICATION THEREOF | Chengdu Kuachangaopu Medical Technology Co., Ltd. (CN) | 2023-08-09 | — | — | EP | disclosed |
| CN-111809068-B | Preparation method of ammonium metavanadate for all-vanadium redox flow battery | 中国科学院过程工程研究所 | 2020-12-15 | — | — | CN | disclosed |
| CN-111809068-A | Preparation method of ammonium metavanadate for all-vanadium redox flow battery | 中国科学院过程工程研究所 | 2020-10-23 | — | — | CN | disclosed |
| CN-111019933-A | Immobilized laccase, preparation method and application in antibiotic degradation | 天津大学 | 2020-04-17 | — | — | CN | disclosed |
| CN-107722103-A | A kind of extracting method of margosine | 江苏金太阳纺织科技股份有限公司 | 2018-02-23 | — | — | CN | disclosed |
| EP-0678580-B1 | Reagent for measuring direct bilirubin | UNITIKA LTD (JP) | 2007-02-21 | — | — | EP | disclosed |
| EP-1188770-A1 | SUBSTANCE BINDING TO THE SUBSTRATE OF ACTIVATED BLOOD COAGULATION FACTOR IN COMPETITION WITH THIS FACTORTO THEREBY REGULATE THE R EACTION BETWEEN THE ACTIVATED BLOOD COAGULATION FACTOR AND THE SUBSTRATE, A PROCESS FOR PRODUCING THE SUBSTANCE AND BLOOD COAGULATION FACTOR-ADSORBENT WITH THE USE OF THE | FUJIMORI KOGYO CO., LTD. (JP) | 2002-03-20 | — | — | EP | disclosed |
| EP-0387784-B1 | Quantitative determination of bilirubin and a reagent therefor | UNITIKA LTD (JP) | 1997-09-10 | — | — | EP | disclosed |
| US-5599661-A | REAGENT COMPRISES BUFFER, TETRAPYRROLE COMPOUND, BILIRUBIN OXIDIZING COMPOUND OF BILIRUBIN OXIDASE, AN OXIDIZING AGENT, OR A DIAZONIUM SALT | UNITIKA, LTD. (JP) | 1997-02-04 | — | — | US | disclosed |
| EP-0678580-A2 | Reagent for measuring direct bilirubin | UNITIKA LTD. (JP) | 1995-10-25 | — | — | EP | disclosed |
| US-5104794-A | Deconjugation of conjugated bilirubins to be measured using high performance liquid chromatography | UNITIKA LTD. (JP) | 1992-04-14 | — | — | US | disclosed |
| EP-0387784-A2 | Quantitative determination of bilirubin and a reagent therefor | UNITIKA LTD. (JP) | 1990-09-19 | — | — | EP | disclosed |