Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12747584 | 0.79 | L3MBTL1 (0.57) | L3MBTL1POLBADORA2AADORA1FFAR4 | |
| SCHEMBL7295341 | 0.77 | SPHK2 (0.59) | L3MBTL1NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL12747582 | 0.77 | L3MBTL1 (0.62) | L3MBTL1POLBADORA2AADORA1TSHR | |
| SCHEMBL783030 | 0.74 | LMNA (0.65) | L3MBTL1POLBADORA2AALDH1A1TSHR | |
| SCHEMBL5165370 | 0.74 | L3MBTL1 (0.54) | L3MBTL1POLBADORA2AALDH1A1TSHR | |
| Acetic Acid SCHEMBL2343497 | 0.73 | TSHR (0.51) | L3MBTL1ALDH1A1TSHRSMN1; SMN2MAPK1 | |
| SCHEMBL6298662 | 0.73 | L3MBTL1 (0.52) | L3MBTL1POLBTSHRNPC1RAB9A | |
| SCHEMBL14539768 | 0.73 | L3MBTL1 (0.52) | L3MBTL1TSHRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7116372 | 0.72 | L3MBTL1 (0.59) | L3MBTL1ALDH1A1TSHRFFAR4NPC1 | |
| SCHEMBL6565112 | 0.72 | L3MBTL1 (0.59) | L3MBTL1POLBADORA2AADORA1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7273867-B2 | Phenyl derivatives | MERCK PATENT GMBH (DE) | 2007-09-25 | — | — | US | disclosed |
| EP-1351938-B1 | PHENYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-04-11 | — | — | EP | disclosed |
| US-6946489-B2 | Substituted biphenyl derivatives | MERCK PATENT GMBH (DE) | 2005-09-20 | — | — | US | disclosed |
| US-20040220241-A1 | Substituted biphenyl derivatives | MERCK PATENT GMBH (DE) | 2004-11-04 | — | — | US | disclosed |
| US-20040087582-A1 | Phenyl derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2004-05-06 | — | — | US | disclosed |
| EP-1351938-A1 | PHENYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002057236-A1 | PHENYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2002-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040220241-A1 | Substituted biphenyl derivatives | APOB, F2R, BDKRB1 | L3MBTL1 1536/4885POLB 675/4885RECQL 276/4885 |
| US-20040087582-A1 | Phenyl derivatives | F2, F11, SERPINC1 | L3MBTL1 389/4885POLB 4221/4885RECQL 398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.