Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.56 |
| ▸ | PDE5A | O76074 | 3/20 | 0.46 |
| ▸ | METAP1 | P53582 | 2/20 | 0.46 |
| ▸ | METAP2 | P50579 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | FLT1 | P17948 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 5/20 | 0.42 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL569578 | 0.83 | NUDT1 (0.51) | NUDT1PDE5AMETAP1METAP2AURKA | |
| SCHEMBL10466026 | 0.75 | NUDT1 (0.44) | NUDT1PDE5AMETAP1METAP2AURKA | |
| SCHEMBL29815201 | 0.73 | L3MBTL1 (0.68) | NUDT1METAP1METAP2CA2MAPK1 | |
| SCHEMBL830431 | 0.73 | L3MBTL1 (0.68) | NUDT1METAP1METAP2CA2MAPK1 | |
| SCHEMBL10466652 | 0.72 | L3MBTL1 (0.49) | NUDT1CA1CA2MAPK1CA9 | |
| SCHEMBL8354989 | 0.72 | METAP2 (0.42) | METAP1METAP2 | |
| SCHEMBL3997824 | 0.72 | NUDT1 (0.75) | NUDT1PDE5AMETAP1METAP2FGFR1 | |
| SCHEMBL3998276 | 0.72 | NUDT1 (0.75) | NUDT1PDE5AMETAP1METAP2FGFR1 | |
| SCHEMBL323981 | 0.72 | NUDT1 (0.60) | NUDT1PDE5AMETAP1METAP2FGFR1 | |
| SCHEMBL42319 | 0.72 | NUDT1 (1.00) | NUDT1PDE5AMETAP1METAP2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115322190-B | Pyridoimidazole acyl sulfonamide derivative, and preparation method and application thereof | 山东大学 | 2023-09-22 | — | — | CN | disclosed |
| US-20180273534-A1 | PYRAZOLOPYRIDINE SULFONAMIDES AS NEMATICIDES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-09-27 | — | — | US | disclosed |
| US-10059706-B2 | Pyrazolopyridine sulfonamides as nematicides | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-08-28 | — | — | US | disclosed |
| CN-105578885-B | Imidazo thiophene (two) azoles sulfonamide as nematicide | 拜耳作物科学股份公司 | 2018-06-26 | — | — | CN | disclosed |
| CN-106661022-B | Pyrazolopyridine sulfonamides as nematicides | 拜耳作物科学股份公司 | 2018-05-04 | — | — | CN | disclosed |
| EP-3139743-B1 | PYRAZOLOPYRIDINE SULFONAMIDES AS NEMATICIDES | BAYER CROPSCIENCE AG (DE) | 2018-03-14 | — | — | EP | disclosed |
| US-9789118-B2 | Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof | NOVARTIS AG (CH) | 2017-10-17 | — | — | US | disclosed |
| EP-3024330-B1 | IMIDAZOTHIA(DIA)ZOLE SULFONAMIDES AS NEMATICIDES | BAYER CROPSCIENCE AG (DE) | 2017-08-30 | — | — | EP | disclosed |
| CN-106661022-A | Pyrazolopyridine sulfonamides as nematicides | 拜耳作物科学股份公司 | 2017-05-10 | — | — | CN | disclosed |
| US-20170088548-A1 | PYRAZOLOPYRIDINE SULFONAMIDES AS NEMATICIDES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2017-03-30 | — | — | US | disclosed |
| US-8697739-B2 | Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof | NOVARTIS AG (CH) | 2014-04-15 | — | — | US | disclosed |
| US-20120028969-A1 | BICYCLIC ACETYL-COA CARBOXYLASE INHIBITORS AND USES THEREOF | NOVARTIS AG (CH) | 2012-02-02 | — | — | US | disclosed |
| CN-101014596-A | Imidazoquinolinylsulfonamides, imidazopyridinylsulfonamides, and imidazo-1, 5-naphthyridinylsulfonamides | 3M INNOVATIVE PROPERTIES CO (US) | 2007-08-08 | — | — | CN | disclosed |
| US-4943570-A | GASTROINTESTINAL DISORDERS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1990-07-24 | — | — | US | disclosed |
| US-4943570-A | GASTROINTESTINAL DISORDERS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1990-07-24 | — | — | US | disclosed |
| US-4943570-A | GASTROINTESTINAL DISORDERS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1990-07-24 | — | — | US | disclosed |
| US-4933338-A | ANTIULCER AGENTS, ANTISECRETORY AGENTS, TREATMENT OF GASTROINTESTINAL DISORDERS; CHEMICAL INTERMEDIATES | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1990-06-12 | — | — | US | disclosed |
| US-4933338-A | ANTIULCER AGENTS, ANTISECRETORY AGENTS, TREATMENT OF GASTROINTESTINAL DISORDERS; CHEMICAL INTERMEDIATES | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1990-06-12 | — | — | US | disclosed |
| EP-0246126-A1 | Benzimidazoles and imidazopyridine sulfone amides, process for their preparation and their use as medicaments | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1987-11-19 | — | — | EP | disclosed |
| EP-0246126-A1 | Benzimidazoles and imidazopyridine sulfone amides, process for their preparation and their use as medicaments | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1987-11-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170088548-A1 | PYRAZOLOPYRIDINE SULFONAMIDES AS NEMATICIDES | NISCH, CATSPER1, KCNH1 | NUDT1 1043/4885PDE5A 1117/4885METAP1 1385/4885 |
| US-20180273534-A1 | PYRAZOLOPYRIDINE SULFONAMIDES AS NEMATICIDES | NISCH, CATSPER1, KCNH1 | NUDT1 1043/4885PDE5A 1117/4885METAP1 1385/4885 |
| US-20120028969-A1 | BICYCLIC ACETYL-COA CARBOXYLASE INHIBITORS AND USES THEREOF | ACACA, ACACB, COASY | NUDT1 2147/4885PDE5A 2063/4885METAP1 1641/4885 |
| US-10059706-B2 | Pyrazolopyridine sulfonamides as nematicides | NISCH, CATSPER1, KCNH1 | NUDT1 1043/4885PDE5A 1117/4885METAP1 1385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.