Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | SCN1A | P35498 | 3/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.39 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 4/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL38561 | 0.90 | HTR6 (0.36) | MAOACYP3A4SCN1ASCN2ASCN3A | |
| Ethylenediamine SCHEMBL408137 | 0.84 | LIPG (0.47) | LIPGTLR8 | |
| Ethylenediamine SCHEMBL30441324 | 0.84 | LIPG (0.47) | LIPGTLR8 | |
| SCHEMBL2695711 | 0.83 | LIPG (0.53) | LIPGTHRB | |
| SCHEMBL8745299 | 0.83 | MGLL (0.41) | MGLLLIPG | |
| SCHEMBL2855251 | 0.83 | LIPG (0.53) | LIPGTHRB | |
| SCHEMBL4135127 | 0.83 | LIPG (0.53) | LIPGTHRB | |
| SCHEMBL6301417 | 0.83 | LIPG (0.53) | LIPGTHRB | |
| SCHEMBL2233360 | 0.83 | LIPG (0.53) | LIPGTHRB | |
| SCHEMBL10824045 | 0.83 | LIPG (0.53) | LIPGTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773916-B1 | PROCESS FOR PREPARATION OF FUNCTIONALIZED POLYIMIDES | SABIC INNOVATIVE PLASTICS IP (NL) | 2014-02-12 | — | — | EP | disclosed |
| EP-1773916-A1 | PROCESS FOR PREPARATION OF FUNCTIONALIZED POLYIMIDES | The General Electric Company (US) | 2007-04-18 | — | — | EP | disclosed |
| US-7148314-B2 | Process for preparation of functionalized polyimides | GENERAL ELECTRIC COMPANY (US) | 2006-12-12 | — | — | US | disclosed |
| WO-2006014448-A1 | PROCESS FOR PREPARATION OF FUNCTIONALIZED POLYIMIDES | GENERAL ELECTRIC COMPANY (US) | 2006-02-09 | — | — | WO | disclosed |
| US-20060009613-A1 | Process for preparation of of functionalized polyimides | GENERAL ELECTRIC COMPANY | 2006-01-12 | — | — | US | disclosed |