Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.35 |
| ▸ | SCN1A | P35498 | 2/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5167637 | 0.90 | MAOA (0.40) | HTR6SCN1ASCN2ASCN3AKDM4E | |
| SCHEMBL39171 | 0.85 | TAAR1 (0.45) | HTR6F2PRSS1PRSS2PRSS3 | |
| Potassium Ion SCHEMBL3216153 | 0.82 | LIPG (0.43) | CYP3A4CYP2C9CA1CA2 | |
| SCHEMBL28043042 | 0.81 | CA2 (0.45) | CYP2C9TAAR1MGLLCA1CA2 | |
| Ethylenediamine SCHEMBL408137 | 0.81 | LIPG (0.47) | CA2 | |
| Ethylenediamine SCHEMBL30441324 | 0.81 | LIPG (0.47) | CA2 | |
| Potassium Ion SCHEMBL23749114 | 0.81 | LIPG (0.50) | CA2 | |
| SCHEMBL1806284 | 0.80 | MYC (0.40) | HTR6SCN1ASCN2ASCN3AKDM4E | |
| Potassium Ion SCHEMBL6928318 | 0.79 | LIPG (0.53) | — | |
| Potassium Ion SCHEMBL21822103 | 0.79 | LIPG (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448997-B1 | MODIFIED POLYAMIDE COMPOSITION | RHODIA OPERATIONS (FR) | 2018-10-03 | — | — | EP | claimed |
| EP-2576658-B1 | SULFONATE-MODIFIED POLYAMIDE HAVING IMPROVED BARRIER PROPERTIES | RHODIA OPERATIONS S A (FR) | 2018-07-11 | — | — | EP | claimed |
| US-9732222-B2 | Modified polyamide composition | RHODIA OPERATIONS (FR) | 2017-08-15 | — | — | US | claimed |
| US-20130150524-A1 | SULFONATE-MODIFIED POLYAMIDE HAVING IMPROVED BARRIER PROPERTIES | RHODIA OPERATIONS (FR) | 2013-06-13 | — | — | US | claimed |
| EP-2576658-A1 | SULFONATE-MODIFIED POLYAMIDE HAVING IMPROVED BARRIER PROPERTIES | Rhodia Operations S.A. (FR) | 2013-04-10 | — | — | EP | claimed |
| US-20120172521-A1 | MODIFIED POLYAMIDE COMPOSITION | RHODIA OPERATIONS (FR) | 2012-07-05 | — | — | US | claimed |
| EP-2448997-A1 | MODIFIED POLYAMIDE COMPOSITION | Rhodia Opérations (FR) | 2012-05-09 | — | — | EP | claimed |
| WO-2011147739-A1 | SULFONATE-MODIFIED POLYAMIDE HAVING IMPROVED BARRIER PROPERTIES | RHODIA OPERATIONS (FR) | 2011-12-01 | — | — | WO | claimed |
| WO-2011000763-A1 | MODIFIED POLYAMIDE COMPOSITION | RHODIA OPERATIONS (FR) | 2011-01-06 | — | — | WO | claimed |
| EP-2448997-B1 | MODIFIED POLYAMIDE COMPOSITION | RHODIA OPERATIONS (FR) | 2018-10-03 | — | — | EP | disclosed |
| EP-2576658-B1 | SULFONATE-MODIFIED POLYAMIDE HAVING IMPROVED BARRIER PROPERTIES | RHODIA OPERATIONS S A (FR) | 2018-07-11 | — | — | EP | disclosed |
| EP-2448998-B1 | MODIFIED POLYAMIDE, PREPARATION METHOD THEREOF AND ARTICLE OBTAINED FROM SAID POLYAMIDE | RHODIA OPERATIONS (FR) | 2018-04-25 | — | — | EP | disclosed |
| US-9732222-B2 | Modified polyamide composition | RHODIA OPERATIONS (FR) | 2017-08-15 | — | — | US | disclosed |
| US-8952122-B2 | Modified polyamide, preparation method thereof and article obtained from said polyamide | RHODIA OPERATIONS (FR) | 2015-02-10 | — | — | US | disclosed |
| US-20120172521-A1 | MODIFIED POLYAMIDE COMPOSITION | RHODIA OPERATIONS (FR) | 2012-07-05 | — | — | US | disclosed |
| EP-2448997-A1 | MODIFIED POLYAMIDE COMPOSITION | Rhodia Opérations (FR) | 2012-05-09 | — | — | EP | disclosed |
| EP-2448998-A1 | MODIFIED POLYAMIDE, PREPARATION METHOD THEREOF AND ARTICLE OBTAINED FROM SAID POLYAMIDE | Rhodia Opérations (FR) | 2012-05-09 | — | — | EP | disclosed |
| WO-2011147739-A1 | SULFONATE-MODIFIED POLYAMIDE HAVING IMPROVED BARRIER PROPERTIES | RHODIA OPERATIONS (FR) | 2011-12-01 | — | — | WO | disclosed |
| WO-2011000763-A1 | MODIFIED POLYAMIDE COMPOSITION | RHODIA OPERATIONS (FR) | 2011-01-06 | — | — | WO | disclosed |
| WO-2011000764-A1 | MODIFIED POLYAMIDE, PREPARATION METHOD THEREOF AND ARTICLE OBTAINED FROM SAID POLYAMIDE | RHODIA OPERATIONS (FR) | 2011-01-06 | — | — | WO | disclosed |