Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 3/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5494468 | 0.87 | CTSD (0.51) | RENKLK5CTSD | |
| SCHEMBL6847601 | 0.79 | ALDH1A1 (0.40) | CTSDALDH1A1BACE1TACR1CYP1A2 | |
| SCHEMBL4426250 | 0.75 | CASP3 (0.58) | RENCTSD | |
| SCHEMBL27564532 | 0.75 | CTSK (0.59) | REN | |
| SCHEMBL625910 | 0.73 | CTSD (0.44) | RENKLK5CTSD | |
| SCHEMBL10073352 | 0.73 | CTSD (0.44) | RENKLK5CTSD | |
| SCHEMBL4434235 | 0.73 | CTSD (0.44) | RENKLK5CTSD | |
| SCHEMBL5175236 | 0.72 | ALDH1A1 (0.53) | ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7093970 | 0.72 | TRPA1 (0.46) | REN | |
| SCHEMBL5174687 | 0.71 | SYK (0.42) | KLK5TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177168-B1 | CASPASE INHIBITORS AND THE USE THEREOF | CYTOVIA INC (US) | 2007-05-30 | — | — | EP | disclosed |
| US-20040116355-A1 | Caspase inhibitors and the use thereof | CYTOVIA, INC. | 2004-06-17 | — | — | US | disclosed |
| US-6716818-B2 | DIPEPTIDE DERIVATIVES | CYTOVIA, INC. | 2004-04-06 | — | — | US | disclosed |
| EP-1177168-A4 | CASPASE INHIBITORS AND THE USE THEREOF | CYTOVIA INC (US) | 2003-06-25 | — | — | EP | disclosed |
| US-20020058631-A1 | Caspase inhibitors and the use thereof | CYTOVIA, INC. | 2002-05-16 | — | — | US | disclosed |
| US-6355618-B1 | ENZYME INHIBITORS | CYTOVIA, INC. | 2002-03-12 | — | — | US | disclosed |
| EP-1177168-A1 | CASPASE INHIBITORS AND THE USE THEREOF | Cytovia, Inc. (US) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000061542-A1 | CASPASE INHIBITORS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2000-10-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020058631-A1 | Caspase inhibitors and the use thereof | CASP1, CASP3, CASP10 | REN 515/4885KLK5 1579/4885CTSD 94/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.