Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5193335 | 0.91 | SMN1; SMN2 (0.49) | GAAPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL5190900 | 0.87 | POLB (0.49) | GAAPOLBKMT2ANPSR1ALDH1A1 | |
| SCHEMBL5192336 | 0.83 | ALDH1A1 (0.51) | GAAMEN1KMT2ASLC18A3ALDH1A1 | |
| SCHEMBL5191569 | 0.77 | ALDH1A1 (0.47) | MEN1KMT2ASLC18A3ALDH1A1HTT | |
| SCHEMBL5192491 | 0.74 | ALDH1A1 (0.45) | GAAMEN1KMT2AALDH1A1PKM | |
| SCHEMBL5191850 | 0.74 | LTA4H (0.49) | POLBSLC18A3PKMSMN1; SMN2KDM4E | |
| SCHEMBL5192443 | 0.74 | ALDH1A1 (0.48) | POLBMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL5193432 | 0.74 | MAPT (0.50) | GAAMEN1KMT2APKMRAB9A | |
| SCHEMBL5194091 | 0.73 | FAAH (0.53) | MEN1KMT2AALDH1A1PKMRAB9A | |
| SCHEMBL5190018 | 0.73 | PKM (0.49) | GAAPOLBMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | disclosed |