Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | HSF1 | Q00613 | 2/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29743004 | 0.75 | KDM4E (0.49) | MAPTPKMKMT2AMEN1ALDH1A1 | |
| SCHEMBL20851548 | 0.75 | KDM4E (0.49) | MAPTPKMKMT2AMEN1ALDH1A1 | |
| SCHEMBL5201190 | 0.73 | MAPK14 (0.33) | MAPK14HCRTR1HCRTR2ALDH1A1KDM4E | |
| SCHEMBL4641452 | 0.72 | SCN10A (0.35) | HCRTR1HCRTR2 | |
| SCHEMBL5202337 | 0.71 | KDM4E (0.36) | MAPK14KMT2AMEN1HSF1HCRTR1 | |
| SCHEMBL5202000 | 0.71 | MEN1 (0.33) | KMT2AMEN1HCRTR1HCRTR2 | |
| SCHEMBL5204446 | 0.68 | HCRTR1 (0.37) | MAPK14KMT2AMEN1HCRTR1HCRTR2 | |
| SCHEMBL5203615 | 0.68 | UCHL1 (0.38) | HCRTR1HCRTR2 | |
| SCHEMBL4640604 | 0.66 | AADAT (0.45) | KMT2AMEN1KDM4ETSHRNPSR1 | |
| SCHEMBL26092526 | 0.64 | MAPT (0.44) | MAPTPKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817030-A2 | INDUCIBLE NITRIC OXIDE SYNTHASE DIMERIZATION INHIBITORS | Kalypsys, Inc. (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006060424-A2 | INDUCIBLE NITRIC OXIDE SYNTHASE DIMERIZATION INHIBITORS | KALYPSYS, INC. (US) | 2006-06-08 | — | — | WO | disclosed |