Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
| ▸ | CES1 | P23141 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8492283 | 1.00 | LMNA (0.43) | LMNAMAPK1SRCCYP2D6CES2 | |
| SCHEMBL9544281 | 1.00 | LMNA (0.43) | LMNAMAPK1SRCCYP2D6CES2 | |
| Ammonia Solution, Strong SCHEMBL10442664 | 0.98 | LMNA (0.41) | LMNAMAPK1SRCCYP2D6CES2 | |
| SCHEMBL8858822 | 0.98 | LMNA (0.44) | LMNAMAPK1SRCCYP2D6CES2 | |
| SCHEMBL9540931 | 0.98 | LMNA (0.44) | LMNAMAPK1SRCCYP2D6CES2 | |
| Potassium Ion SCHEMBL9296986 | 0.95 | LMNA (0.43) | LMNAMAPK1SRCCYP2D6CES2 | |
| Zinc Ion SCHEMBL7745848 | 0.95 | LMNA (0.43) | LMNAMAPK1SRCCYP2D6CES2 | |
| Ammonia Solution, Strong SCHEMBL21495185 | 0.95 | LMNA (0.43) | LMNAMAPK1SRCCYP2D6CES2 | |
| Water SCHEMBL21046213 | 0.95 | LMNA (0.43) | LMNAMAPK1SRCCYP2D6CES2 | |
| Ammonia Solution, Strong SCHEMBL9515772 | 0.95 | LMNA (0.43) | LMNAMAPK1SRCCYP2D6CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992016262-A1 | IMMOBILIZATION OF LEAD IN SOLID RESIDUES FROM RECLAIMING METALS | WHEELABRATOR ENVIRONMENTAL SYSTEMS, INC. (US) | 1992-10-01 | — | — | WO | claimed |
| EP-0404226-A1 | Process for purifying products containing esters of a non-reducing sugar and one or more fatty acids | COÖPERATIEVE VERENIGING SUIKER UNIE U.A. (NL) | 1990-12-27 | — | — | EP | claimed |
| EP-1817049-A1 | SOLUBLE, STABLE INSULIN-CONTAINING FORMULATIONS WITH A PROTAMINE SALT | NOVO NORDISK A/S (DK) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006053906-A1 | SOLUBLE, STABLE INSULIN-CONTAINING FORMULATIONS WITH A PROTAMINE SALT | NOVO NORDISK A/S (DK) | 2006-05-26 | — | — | WO | disclosed |
| EP-0730601-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTIONS | WASHINGTON UNIVERSITY (US) | 1996-09-11 | — | — | EP | disclosed |
| WO-1995014028-A9 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTIONS | — | 1995-08-10 | — | — | WO | disclosed |
| WO-1995014028-A2 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTIONS | WASHINGTON UNIVERSITY (US) | 1995-05-26 | — | — | WO | disclosed |
| EP-0398130-A2 | Heat-resistant expansive member | NIPPON PILLAR PACKING CO. LTD. (JP) | 1990-11-22 | — | — | EP | disclosed |
| EP-0230214-A2 | Process for the preparation of substantially crystalline calcium sodium metaphosphate | Monsanto Company (US) | 1987-07-29 | — | — | EP | disclosed |
| EP-0227630-A2 | Process for the preparation of substantially crystalline calcium sodium metaphosphate | Monsanto Company (US) | 1987-07-01 | — | — | EP | disclosed |