Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 7/20 | 0.36 |
| ▸ | HPN | P05981 | 2/20 | 0.36 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.36 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | F11 | P03951 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | SMO | Q99835 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202889 | 0.80 | HPN (0.52) | ADAM17HPNST14HGFACKMT2A | |
| SCHEMBL5205062 | 0.78 | SMO (0.46) | ALDH1A1SMOLMNAPOLBHTT | |
| SCHEMBL5203062 | 0.71 | HCRTR1 (0.49) | ALDH1A1HTR6LMNAPOLBTHRB | |
| SCHEMBL4860552 | 0.67 | HRH2 (0.46) | KMT2AALDH1A1LMNA | |
| SCHEMBL5822858 | 0.65 | HRH2 (0.35) | SMO | |
| SCHEMBL5202142 | 0.65 | LMNA (0.50) | ALDH1A1HTR6SMOLMNAPOLB | |
| SCHEMBL5206068 | 0.64 | LMNA (0.49) | ALDH1A1HTR6SMOLMNAPOLB | |
| SCHEMBL4859112 | 0.64 | RORC (0.47) | ALDH1A1HTR6LMNAPOLB | |
| SCHEMBL4854486 | 0.63 | ALDH1A1 (0.46) | KMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL4851493 | 0.63 | MEN1 (0.45) | KMT2AMEN1HTR6ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007501828-A | — | — | 2007-02-01 | — | — | JP | claimed |
| EP-1654253-A1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2006-05-10 | — | — | EP | claimed |
| WO-2005019208-A1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2005-03-03 | — | — | WO | claimed |