Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | OGA | O60502 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5238383 | 0.86 | GPR119 (0.32) | HDAC3HDAC1HDAC2HDAC8GPR119 | |
| SCHEMBL5237168 | 0.80 | NPC1 (0.36) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL5237297 | 0.79 | KDM4E (0.40) | KDM4ESLC6A7 | |
| SCHEMBL5236884 | 0.79 | SLC6A7 (0.48) | SLC6A7 | |
| SCHEMBL5238192 | 0.78 | CYP2C19 (0.37) | NPC1RAB9AMEN1KMT2A | |
| SCHEMBL5236354 | 0.78 | CHRNB2 (0.38) | — | |
| SCHEMBL5237172 | 0.77 | AOC3 (0.37) | — | |
| SCHEMBL5235197 | 0.77 | HSD17B10 (0.45) | KDM4E | |
| SCHEMBL5231485 | 0.76 | HTR3A (0.44) | HDAC1 | |
| SCHEMBL5235194 | 0.75 | PKM (0.44) | KMT2AKDM4EOGASLC6A7ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |