Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.36 |
| ▸ | MIF | P14174 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | DDT | P30046 | 3/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5244708 | 0.91 | DDT (0.35) | MIFROCK2GRM5NAMPTDDT | |
| SCHEMBL5246767 | 0.89 | MIF (0.47) | BRD4MIFDDTPSEN1PSEN2 | |
| SCHEMBL5244706 | 0.89 | ROCK2 (0.40) | BRD4MIFROCK2DDTROCK1 | |
| SCHEMBL5244462 | 0.88 | MAPT (0.40) | BRD4MIF | |
| SCHEMBL5245935 | 0.87 | ROCK2 (0.41) | BRD4MIFROCK2DDTROCK1 | |
| SCHEMBL5247395 | 0.86 | DDT (0.43) | MIFDDTPSEN1PSEN2APH1B | |
| SCHEMBL5246709 | 0.86 | ROCK2 (0.42) | BRD4MIFROCK2DDTROCK1 | |
| SCHEMBL5247966 | 0.86 | EPHX2 (0.43) | MIF | |
| SCHEMBL5247657 | 0.86 | LMNA (0.46) | BRD4MIFDDT | |
| SCHEMBL5247626 | 0.86 | MIF (0.48) | MIFMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1867331-A1 | TRIAZOLE DERIVATIVE AND THE USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2007-12-19 | — | — | EP | disclosed |