Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | FAP | Q12884 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11530558 | 0.95 | GPR84 (0.39) | SIGMAR1MAPK1SLC6A3SLC6A2DRD3 | |
| SCHEMBL4625385 | 0.81 | SIGMAR1 (0.36) | SIGMAR1CA2SLC6A3SLC6A2DRD3 | |
| SCHEMBL22500187 | 0.73 | SIGMAR1 (0.48) | SIGMAR1MAPK1CA2SLC6A3SLC6A2 | |
| SCHEMBL3261112 | 0.72 | CA2 (0.56) | MAPK1CA2SLC6A3DRD3MAPT | |
| SCHEMBL10336334 | 0.72 | ALDH1A1 (0.38) | MAPTGPR84 | |
| SCHEMBL24465088 | 0.71 | S1PR1 (0.37) | SIGMAR1SLC6A3SLC6A2DRD3USP2 | |
| SCHEMBL19403269 | 0.71 | S1PR1 (0.42) | SIGMAR1MAPK1CA2SLC6A3SLC6A2 | |
| SCHEMBL19605846 | 0.71 | S1PR1 (0.42) | SIGMAR1MAPK1CA2SLC6A3SLC6A2 | |
| SCHEMBL577633 | 0.71 | CA2 (0.48) | MAPK1CA2SLC6A3DRD3MAPT | |
| SCHEMBL1672001 | 0.71 | CA1 (0.47) | MAPK1CA2MAPTCA1SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120088844-A1 | CHAIN-EXTENDED POLYSILOXANE CROSSLINKERS WITH DANGLING HYDROPHILIC POLYMER CHAINS | ALCON INC. (CH) | 2012-04-12 | — | — | US | claimed |
| US-9422447-B2 | Azetidinium-containing copolymers and uses thereof | NOVARTIS AG (CH) | 2016-08-23 | — | — | US | disclosed |
| US-9261626-B2 | Contact lenses with enzymatically degradable coatings thereon | NOVARTIS AG (CH) | 2016-02-16 | — | — | US | disclosed |
| US-9244195-B2 | Silicone hydrogel lenses with nano-textured surfaces | NOVARTIS AG (CH) | 2016-01-26 | — | — | US | disclosed |
| US-9097840-B2 | Amphiphilic siloxane-containing (meth)acrylamides and uses thereof | NOVARTIS AG (CH) | 2015-08-04 | — | — | US | disclosed |
| US-9052440-B2 | Chain-extended polysiloxane crosslinkers with dangling hydrophilic polymer chains | NOVARTIS AG (CH) | 2015-06-09 | — | — | US | disclosed |
| US-20140350124-A1 | CHAIN-EXTENDED POLYSILOXANE CROSSLINKERS WITH DANGLING HYDROPHILIC POLYMER CHAINS | ALCON INC. (CH) | 2014-11-27 | — | — | US | disclosed |
| US-8835525-B2 | Chain-extended polysiloxane crosslinkers with dangling hydrophilic polymer chains | NOVARTIS AG (CH) | 2014-09-16 | — | — | US | disclosed |
| US-20140171539-A1 | AMPHIPHILIC SILOXANE-CONTAINING (METH)ACRYLAMIDES AND USES THEREOF | NOVARTIS AG (CH) | 2014-06-19 | — | — | US | disclosed |
| US-20140171542-A1 | AMPHIPHILIC SILOXANE-CONTAINING VINYLIC MONOMERS AND USES THEREOF | NOVARTIS AG (CH) | 2014-06-19 | — | — | US | disclosed |
| US-20130337160-A1 | AZETIDINIUM-CONTAINING COPOLYMERS AND USES THEREOF | ALCON INC. (CH) | 2013-12-19 | — | — | US | disclosed |
| US-8557940-B2 | Amphiphilic polysiloxane prepolymers and uses thereof | NOVARTIS AG (CH) | 2013-10-15 | — | — | US | disclosed |
| US-20130148077-A1 | CONTACT LENSES WITH ENZYMATICALLY DEGRADABLE COATINGS THEREON | NOVARTIS AG (CH) | 2013-06-13 | — | — | US | disclosed |
| US-20120314185-A1 | SILICONE HYDROGEL LENSES WITH NANO-TEXTURED SURFACES | ALCON INC. (CH) | 2012-12-13 | — | — | US | disclosed |
| US-20120088843-A1 | POLYMERIZABLE CHAIN-EXTENDED POLYSILOXANES WITH PENDANT HYDROPHILIC GROUPS | ALCON INC. (CH) | 2012-04-12 | — | — | US | disclosed |
| US-20120088844-A1 | CHAIN-EXTENDED POLYSILOXANE CROSSLINKERS WITH DANGLING HYDROPHILIC POLYMER CHAINS | ALCON INC. (CH) | 2012-04-12 | — | — | US | disclosed |
| US-20120029111-A1 | AMPHIPHILIC POLYSILOXANE PREPOLYMERS AND USES THEREOF | ALCON INC. (CH) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088843-A1 | POLYMERIZABLE CHAIN-EXTENDED POLYSILOXANES WITH PENDANT HYDROPHILIC GROUPS | GFER, DRD1, SORD | SIGMAR1 155/4885MAPK1 4036/4885CA2 2730/4885 |
| US-20120029111-A1 | AMPHIPHILIC POLYSILOXANE PREPOLYMERS AND USES THEREOF | PIGS, ELOVL1, HACD2 | SIGMAR1 1744/4885MAPK1 4175/4885CA2 3970/4885 |
| US-20120088844-A1 | CHAIN-EXTENDED POLYSILOXANE CROSSLINKERS WITH DANGLING HYDROPHILIC POLYMER CHAINS | HACD2, HACD3, PCNA | SIGMAR1 1188/4885MAPK1 3316/4885CA2 1019/4885 |
| US-20140350124-A1 | CHAIN-EXTENDED POLYSILOXANE CROSSLINKERS WITH DANGLING HYDROPHILIC POLYMER CHAINS | HACD2, HACD3, PCNA | SIGMAR1 1188/4885MAPK1 3316/4885CA2 1019/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.