Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 3/20 | 0.39 |
| ▸ | PGR | P06401 | 3/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 5/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068700 | 0.81 | NR3C1 (0.60) | NR3C1PGRNR3C2ADAM17 | |
| SCHEMBL4414553 | 0.70 | NR3C2 (0.59) | NR3C1PGRNR3C2HTR6 | |
| SCHEMBL5262707 | 0.69 | NR3C1 (0.46) | NR3C1PGRNR3C2ALDH1A1MAPT | |
| SCHEMBL4448878 | 0.69 | NR3C1 (0.43) | NR3C1PGRNR3C2ALDH1A1MEN1 | |
| SCHEMBL4406085 | 0.68 | NR3C1 (0.54) | NR3C1PGRNR3C2HTR6 | |
| SCHEMBL4440691 | 0.68 | ALDH1A1 (0.43) | NR3C1PGRNR3C2ALDH1A1MAPT | |
| SCHEMBL19193000 | 0.66 | ADRB2 (0.63) | HTR6MEN1KMT2A | |
| SCHEMBL4410351 | 0.66 | MTNR1A (0.55) | NR3C1PGRNR3C2ALDH1A1MEN1 | |
| SCHEMBL4446665 | 0.65 | NR3C2 (0.46) | NR3C1PGRNR3C2MAPTMEN1 | |
| SCHEMBL14041509 | 0.65 | HTR6 (0.48) | PGRHTR6PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836166-A2 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006071609-A2 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2006-07-06 | — | — | WO | disclosed |