Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.67 |
| ▸ | CCR3 | P51677 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5276521 | 0.88 | ACHE (0.61) | HTR1ASLC6A4 | |
| SCHEMBL5277741 | 0.85 | CCR3 (0.61) | CCR3 | |
| SCHEMBL5284466 | 0.83 | HTR7 (0.54) | CCR3 | |
| SCHEMBL5276756 | 0.82 | SIGMAR1 (0.56) | CCR3 | |
| SCHEMBL1334517 | 0.80 | ABCB1 (0.60) | HTR1ASLC6A4 | |
| SCHEMBL5279443 | 0.80 | CCR3 (0.65) | HTR1ASLC6A4CCR3 | |
| SCHEMBL1333820 | 0.79 | HTR1A (0.71) | HTR1ASLC6A4 | |
| SCHEMBL5279438 | 0.77 | CCR3 (0.55) | CCR3 | |
| SCHEMBL17325326 | 0.77 | SIGMAR1 (0.56) | HTR1ASLC6A4CCR3 | |
| SCHEMBL16056670 | 0.77 | KCNH2 (0.72) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406623-B1 | SUBSTITUTED 1-PHENETHYLPIPERIDINE COMPOUNDS USED AS INTER ALIA ANALGESICS | GRUENENTHAL GMBH (DE) | 2007-12-12 | — | — | EP | claimed |
| EP-1406623-B1 | SUBSTITUTED 1-PHENETHYLPIPERIDINE COMPOUNDS USED AS INTER ALIA ANALGESICS | GRUENENTHAL GMBH (DE) | 2007-12-12 | — | — | EP | disclosed |
| US-20040171640-A1 | Substituted 1-phenethylpiperidine compounds used as inter alia analgesics | GRUNENTHAL GMBH (DE) | 2004-09-02 | — | — | US | disclosed |
| EP-1406623-A1 | SUBSTITUTED 1-PHENETHYLPIPERIDINE COMPOUNDS USED AS INTER ALIA ANALGESICS | Grünenthal GmbH (DE) | 2004-04-14 | — | — | EP | disclosed |
| WO-2003004026-A1 | SUBSTITUTED 1-PHENETHYLPIPERIDINE COMPOUNDS USED AS INTER ALIA ANALGESICS | Grünenthal GmbH (DE) | 2003-01-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171640-A1 | Substituted 1-phenethylpiperidine compounds used as inter alia analgesics | PNMT, OPRK1, OPRM1 | HTR1A 11/4885SLC6A4 352/4885CCR3 2603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.