Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.54 |
| ▸ | CCR3 | P51677 | 1/20 | 0.51 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.51 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5277741 | 0.88 | CCR3 (0.61) | CCR3CARM1PRMT6KCNH2 | |
| SCHEMBL5279438 | 0.87 | CCR3 (0.55) | CCR3CARM1PRMT6KCNH2CHRM4 | |
| SCHEMBL5276756 | 0.85 | SIGMAR1 (0.56) | CCR3CARM1PRMT6CHRM4 | |
| SCHEMBL5281397 | 0.83 | HTR1A (0.67) | CCR3 | |
| SCHEMBL16653309 | 0.82 | MAPT (0.50) | CCR3 | |
| SCHEMBL2673237 | 0.81 | CA12 (0.57) | CARM1PRMT6 | |
| SCHEMBL5276530 | 0.80 | CCR3 (0.55) | CCR3CARM1PRMT6 | |
| SCHEMBL5276521 | 0.77 | ACHE (0.61) | — | |
| SCHEMBL8085499 | 0.75 | L3MBTL1 (0.63) | HTR7 | |
| SCHEMBL29381887 | 0.75 | CCR3 (0.75) | CCR3CARM1PRMT6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406623-B1 | SUBSTITUTED 1-PHENETHYLPIPERIDINE COMPOUNDS USED AS INTER ALIA ANALGESICS | GRUENENTHAL GMBH (DE) | 2007-12-12 | — | — | EP | claimed |
| EP-1406623-B1 | SUBSTITUTED 1-PHENETHYLPIPERIDINE COMPOUNDS USED AS INTER ALIA ANALGESICS | GRUENENTHAL GMBH (DE) | 2007-12-12 | — | — | EP | disclosed |
| US-20040171640-A1 | Substituted 1-phenethylpiperidine compounds used as inter alia analgesics | GRUNENTHAL GMBH (DE) | 2004-09-02 | — | — | US | disclosed |
| EP-1406623-A1 | SUBSTITUTED 1-PHENETHYLPIPERIDINE COMPOUNDS USED AS INTER ALIA ANALGESICS | Grünenthal GmbH (DE) | 2004-04-14 | — | — | EP | disclosed |
| WO-2003004026-A1 | SUBSTITUTED 1-PHENETHYLPIPERIDINE COMPOUNDS USED AS INTER ALIA ANALGESICS | Grünenthal GmbH (DE) | 2003-01-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171640-A1 | Substituted 1-phenethylpiperidine compounds used as inter alia analgesics | PNMT, OPRK1, OPRM1 | HTR7 190/4885CCR3 2603/4885CARM1 594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.