SCHEMBL5331960

SCHEMBL5331960

CCNCCCCc1c(CS(=O)(=O)c2ccccc2)[nH]c2ccccc12

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 1/20 0.46
CHRNA7 P36544 1/20 0.46
CHRNA4 P43681 1/20 0.46
CYP1A2 P05177 2/20 0.43
CYP3A4 P08684 2/20 0.43
HPGD P15428 2/20 0.43
TSHR P16473 2/20 0.43
CYP2C19 P33261 2/20 0.43
MTNR1A P48039 2/20 0.43
MTNR1B P49286 2/20 0.43
TDP1 Q9NUW8 2/20 0.43
KMT2A Q03164 2/20 0.43
MEN1 O00255 1/20 0.43
CYP2C9 P11712 1/20 0.43
ALDH1A1 P00352 2/20 0.41
MAPT P10636 2/20 0.41
CYP2D6 P10635 1/20 0.41
ALOX15 P16050 1/20 0.41
KDM4E B2RXH2 1/20 0.41
POLB P06746 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5330477 0.78 HTR2A (0.57) CHRNB2CHRNA7CHRNA4CYP1A2CYP3A4
Hydrochloric Acid SCHEMBL5332344 0.76 HTR2A (0.54) CHRNB2CHRNA7CHRNA4CYP1A2CYP3A4
SCHEMBL5330718 0.72 HTR6 (0.54) CYP3A4ALDH1A1MAPTHTR2ACYP19A1
SCHEMBL5420154 0.71 EGFR (0.44) CYP3A4CYP2C19KMT2AMEN1CYP2C9
Hydrochloric Acid SCHEMBL11859405 0.69 HTR6 (0.53) CHRNB2CHRNA7CHRNA4CYP1A2CYP3A4
SCHEMBL5335447 0.69 DRD2 (0.50) CHRNA7CYP3A4KMT2AMEN1ALDH1A1
SCHEMBL10501668 0.69 KDM4E (0.57) CYP3A4HPGDTSHRTDP1KMT2A
SCHEMBL9027380 0.68 SIGMAR1 (0.57) GNRHR
SCHEMBL5378791 0.68 CYP19A1 (0.38) CYP1A2CYP3A4HPGDTSHRKMT2A
SCHEMBL5409935 0.67 CHRNB2 (0.60) CHRNB2CHRNA7CHRNA4CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007046112-A1 ARYLTHIOETHER TRYPTAMINE DERIVATIVES AS FUNCTIONAL 5-HT6 LIGANDS SUVEN LIFE SCIENCES INC. (IN) 2007-04-26 WO disclosed