SCHEMBL533533

SCHEMBL533533

O=S(=O)(NCc1ccc(-n2cccn2)cc1)c1cccnc1

nearest known ligand 0.66

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
NAMPT P43490 4/20 0.53
PTGER2 P43116 3/20 0.50
PTGER4 P35408 1/20 0.50
LMNA P02545 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
CYP2C19 P33261 1/20 0.46
MAPT P10636 3/20 0.46
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
PKM P14618 1/20 0.46
IDO1 P14902 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27803030 0.87 NAMPT (0.53) NAMPTMAPTMEN1KMT2APKM
SCHEMBL12549987 0.83 KEAP1 (0.58) LMNASMN1; SMN2MAPTMEN1KMT2A
SCHEMBL12077597 0.82 NAMPT (0.71) NAMPTMEN1KMT2A
SCHEMBL750261 0.80 MEN1 (0.58) NAMPTLMNASMN1; SMN2CYP2C19MAPT
SCHEMBL18725052 0.78 KEAP1 (0.71) NAMPTLMNASMN1; SMN2CYP2C19MAPT
SCHEMBL18725325 0.78 L3MBTL1 (0.53) LMNAMAPTMEN1KMT2APKM
SCHEMBL28120961 0.77 PTGER2 (0.57) NAMPTPTGER2PTGER4MAPTMEN1
SCHEMBL15651151 0.77 CA12 (0.59) NAMPTLMNASMN1; SMN2CYP2C19MAPT
SCHEMBL533757 0.77 LMNA (0.56) NAMPTLMNASMN1; SMN2CYP2C19MAPT
SCHEMBL119971 0.77 MAPT (0.71) NAMPTMAPTMEN1KMT2APKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106458904-B N-substituted sulfonamide compound and process for producing the same 宇部兴产株式会社 2021-12-03 CN disclosed
EP-3156396-B1 METHOD FOR PRODUCING A N-SUBSTITUTED SULFONAMIDE COMPOUND UBE INDUSTRIES (JP) 2021-07-21 EP disclosed
CN-106458903-B Method for producing heteroaromatic sulfonamide compound 宇部兴产株式会社 2021-02-05 CN disclosed
US-10774072-B2 Crystal of N-substituted sulfonamide compound UBE INDUSTRIES, LTD. (JP) 2020-09-15 US disclosed
US-10428046-B2 N-substituted sulfonamide compound and method for producing same UBE INDUSTRIES, LTD. (JP) 2019-10-01 US disclosed
EP-3156395-B1 METHOD FOR PRODUCING HETEROAROMATIC SULFONAMIDE COMPOUND UBE INDUSTRIES (JP) 2019-01-09 EP disclosed
EP-3156395-B1 METHOD FOR PRODUCING HETEROAROMATIC SULFONAMIDE COMPOUND UBE INDUSTRIES (JP) 2019-01-09 EP disclosed
US-20170121288-A1 METHOD FOR PRODUCING HETEROAROMATIC SULFONAMIDE COMPOUND UBE INDUSTRIES, LTD. (JP) 2017-05-04 US disclosed
US-20170121288-A1 METHOD FOR PRODUCING HETEROAROMATIC SULFONAMIDE COMPOUND UBE INDUSTRIES, LTD. (JP) 2017-05-04 US disclosed
US-20170121288-A1 METHOD FOR PRODUCING HETEROAROMATIC SULFONAMIDE COMPOUND UBE INDUSTRIES, LTD. (JP) 2017-05-04 US disclosed
EP-3156395-A1 METHOD FOR PRODUCING HETEROAROMATIC SULFONAMIDE COMPOUND UBE Industries, Ltd. (JP) 2017-04-19 EP disclosed
CN-106458904-A N-substituted sulfonamide compound and method for producing same 宇部兴产株式会社 2017-02-22 CN disclosed
CN-106458903-A Method for producing heteroaromatic sulfonamide compound 宇部兴产株式会社 2017-02-22 CN disclosed
EP-2415763-B1 PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING GLAUCOMA UBE INDUSTRIES (JP) 2016-01-27 EP disclosed
US-20140113907-A1 PYRIDYLAMINOACETIC ACID COMPOUND UBE INDUSTRIES, LTD. (JP) 2014-04-24 US disclosed
US-8648097-B2 Pyridylaminoacetic acid compound UBE INDUSTRIES, LTD. (JP) 2014-02-11 US disclosed
US-20120190852-A1 MEDICAL COMPOSITION FOR TREATMENT OR PROPHYLAXIS OF GLAUCOMA UBE INDUSTRIES, LTD. (JP) 2012-07-26 US disclosed
EP-2415763-A1 PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING GLAUCOMA Ube Industries, Ltd. (JP) 2012-02-08 EP disclosed
US-20110054172-A1 PYRIDYLAMINOACETIC ACID COMPOUND UBE CORPORATION (JP) 2011-03-03 US disclosed
EP-2264009-A1 PYRIDYLAMINOACETIC ACID COMPOUND Ube Industries, Ltd. (JP) 2010-12-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10774072-B2 Crystal of N-substituted sulfonamide compound STS, SLC10A6, CA3 NAMPT 1765/4885PTGER2 2772/4885PTGER4 2952/4885
US-10428046-B2 N-substituted sulfonamide compound and method for producing same STS, CA7, CA4 NAMPT 2197/4885PTGER2 2352/4885PTGER4 2533/4885
US-20170121288-A1 METHOD FOR PRODUCING HETEROAROMATIC SULFONAMIDE COMPOUND PFAS, SULT2A1, ARSA NAMPT 4338/4885PTGER2 1726/4885PTGER4 2554/4885
US-20140113907-A1 PYRIDYLAMINOACETIC ACID COMPOUND PTGER2, PTGER1, PTGDR2 NAMPT 2339/4885PTGER2 1/4885PTGER4 17/4885
US-20110054172-A1 PYRIDYLAMINOACETIC ACID COMPOUND PTGER2, PTGER1, PTGDR2 NAMPT 2422/4885PTGER2 1/4885PTGER4 17/4885
US-20120190852-A1 MEDICAL COMPOSITION FOR TREATMENT OR PROPHYLAXIS OF GLAUCOMA F12, C1S, AKR1C3 NAMPT 3499/4885PTGER2 24/4885PTGER4 133/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.