SCHEMBL5347293

SCHEMBL5347293

Cc1cc(C)cc(-c2cccc3c2C=CC3)c1

nearest known ligand 0.34

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 1/20 0.34
CREBBP Q92793 1/20 0.34
ALDH1A1 P00352 1/20 0.33
MAPT P10636 1/20 0.33
ACHE P22303 1/20 0.32
BRD9 Q9H8M2 1/20 0.32
BRD7 Q9NPI1 1/20 0.32
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
PRKCQ Q04759 1/20 0.30
PRKCD Q05655 1/20 0.30
HTR1A P08908 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5344544 0.88 FYN (0.40) ALDH1A1MAPTACHE
SCHEMBL6537096 0.81 PRCP (0.34) HTR1A
SCHEMBL26606283 0.79 CA1 (0.34) ALDH1A1
SCHEMBL16394708 0.79 RXRA (0.36) ALDH1A1MAPTHTR1A
SCHEMBL319986 0.78 PRCP (0.40) ALDH1A1HTR1A
SCHEMBL5347333 0.77 S1PR4 (0.36) ALDH1A1MAPTACHEMEN1KMT2A
SCHEMBL5349857 0.77 ELANE (0.33) ALDH1A1MAPTACHEMEN1KMT2A
SCHEMBL28424140 0.77 PRCP (0.39) ALDH1A1HTR1A
SCHEMBL5350419 0.76 PTGER1 (0.37) BRD4CREBBPALDH1A1MAPTMEN1
SCHEMBL5343488 0.76 PRKCQ (0.30) MAPTPRKCQPRKCD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105026408-B Metallocene compound, olefin polymer catalyst, the manufacturing method of olefin polymer and olefin polymer 日本聚乙烯株式会社 2018-09-11 CN disclosed
US-10005864-B2 Metallocene compound, catalyst for olefin polymer, method for producing olefin polymer, and olefin polymer JAPAN POLYETHYLENE CORPORATION (JP) 2018-06-26 US disclosed
EP-3078670-B1 METALLOCENE COMPOUND, CATALYST FOR OLEFIN POLYMER, METHOD FOR PRODUCING OLEFIN POLYMER, AND OLEFIN POLYMER JAPAN POLYETHYLENE CORP (JP) 2017-12-27 EP disclosed
US-20170320981-A1 METALLOCENE COMPOUND, CATALYST FOR OLEFIN POLYMER, METHOD FOR PRODUCING OLEFIN POLYMER, AND OLEFIN POLYMER JAPAN POLYETHYLENE CORPORATION (JP) 2017-11-09 US disclosed
US-9783625-B2 Metallocene compound, catalyst for olefin polymer, method for producing olefin polymer, and olefin polymer JAPAN POLYETHYLENE CORPORATION (JP) 2017-10-10 US disclosed
EP-2963045-B1 METHOD FOR PRODUCING OLEFIN POLYMER WITH A METALLOCENE BASED CATALYST, AND OLEFIN POLYMER JAPAN POLYETHYLENE CORP (JP) 2016-12-21 EP disclosed
EP-3078670-A1 METALLOCENE COMPOUND, CATALYST FOR OLEFIN POLYMER, METHOD FOR PRODUCING OLEFIN POLYMER, AND OLEFIN POLYMER Japan Polyethylene Corporation (JP) 2016-10-12 EP disclosed
US-20160009838-A1 METALLOCENE COMPOUND, CATALYST FOR OLEFIN POLYMER, METHOD FOR PRODUCING OLEFIN POLYMER, AND OLEFIN POLYMER JAPAN POLYETHYLENE CORPORATION (JP) 2016-01-14 US disclosed
EP-2963045-A1 METALLOCENE COMPOUND, CATALYST FOR OLEFIN POLYMER, METHOD FOR PRODUCING OLEFIN POLYMER, AND OLEFIN POLYMER Japan Polyethylene Corporation (JP) 2016-01-06 EP disclosed
CN-105026408-A Metallocene compound, catalyst for olefin polymer, method for producing olefin polymer, and olefin polymer JAPAN POLYETHYLENE CORP 2015-11-04 CN disclosed
US-7297747-B2 Polymerization process and polymer composition EXXONMOBIL CHEMICAL PATENTS INC. (US) 2007-11-20 US disclosed
US-7122498-B2 Metallocenes and catalyst compositions derived therefrom EXXONMOBIL CHEMICAL PATENTS INC. (US) 2006-10-17 US disclosed
US-6870016-B1 Polymerization process and polymer composition EXXONMOBIL CHEMICAL PATENTS INC. (US) 2005-03-22 US disclosed
US-20050059785-A1 Polymerization process and polymer composition HART JAMES R (US) 2005-03-17 US disclosed
US-20050054520-A1 Metallocenes and catalyst compositions derived therefrom EXXONMOBIL CHEMICAL PATENT INC. 2005-03-10 US disclosed
EP-1421090-A2 METALLOCENES AND CATALYST COMPOSITIONS DERIVED THEREFROM Exxonmobil Chemical Patents Inc. (US) 2004-05-26 EP disclosed
WO-2003002583-A2 METALLOCENES AND CATALYST COMPOSITIONS DERIVED THEREFROM EXXONMOBIL CHEMICAL PATENTS INC. (US) 2003-01-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170320981-A1 METALLOCENE COMPOUND, CATALYST FOR OLEFIN POLYMER, METHOD FOR PRODUCING OLEFIN POLYMER, AND OLEFIN POLYMER CPNE4, PIN4, PIN1 BRD4 302/4885CREBBP 3073/4885ALDH1A1 2456/4885
US-20160009838-A1 METALLOCENE COMPOUND, CATALYST FOR OLEFIN POLYMER, METHOD FOR PRODUCING OLEFIN POLYMER, AND OLEFIN POLYMER CPNE4, ALOX12, PIN1 BRD4 1203/4885CREBBP 3682/4885ALDH1A1 1383/4885
US-10005864-B2 Metallocene compound, catalyst for olefin polymer, method for producing olefin polymer, and olefin polymer CPNE4, PPOX, PIN1 BRD4 500/4885CREBBP 2945/4885ALDH1A1 2306/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.