SCHEMBL5344544

SCHEMBL5344544

Cc1cccc(-c2cccc3c2C=CC3)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FYN P06241 2/20 0.40
CLK4 Q9HAZ1 2/20 0.40
DYRK1B Q9Y463 2/20 0.40
CHEK1 O14757 1/20 0.40
MAP4K4 O95819 1/20 0.40
ABL1 P00519 1/20 0.40
NTRK1 P04629 1/20 0.40
LCK P06239 1/20 0.40
CSF1R P07333 1/20 0.40
MET P08581 1/20 0.40
PDGFRB P09619 1/20 0.40
PIM1 P11309 1/20 0.40
FGFR1 P11362 1/20 0.40
PDGFRA P16234 1/20 0.40
PRKACA P17612 1/20 0.40
LTK P29376 1/20 0.40
GRK5 P34947 1/20 0.40
KDR P35968 1/20 0.40
FLT3 P36888 1/20 0.40
MAPK8 P45983 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5347293 0.88 BRD4 (0.34) ACHEALDH1A1MAPT
SCHEMBL6537096 0.84 PRCP (0.34) MAOB
SCHEMBL5350419 0.81 PTGER1 (0.37) CLK4DYRK1BABL1TYRO3NISCH
SCHEMBL319986 0.80 PRCP (0.40) KDRPARP10PARP11ALDH1A1
SCHEMBL6649618 0.80 PTGER1 (0.36) CLK4DYRK1BABL1TYRO3NISCH
SCHEMBL17386677 0.80 KIF11 (0.41) ACHERAB9ANPC1ALDH1A1NFKB1
SCHEMBL28424140 0.79 PRCP (0.39) KDRPARP10PARP11ALDH1A1
SCHEMBL5349857 0.79 ELANE (0.33) ACHERAB9ANPC1ALDH1A1MAPT
SCHEMBL5347333 0.79 S1PR4 (0.36) ACHEALDH1A1MAPTSMN1; SMN2
Propane SCHEMBL28734524 0.78 HTR7 (0.37)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10005864-B2 Metallocene compound, catalyst for olefin polymer, method for producing olefin polymer, and olefin polymer JAPAN POLYETHYLENE CORPORATION (JP) 2018-06-26 US disclosed
EP-3078670-B1 METALLOCENE COMPOUND, CATALYST FOR OLEFIN POLYMER, METHOD FOR PRODUCING OLEFIN POLYMER, AND OLEFIN POLYMER JAPAN POLYETHYLENE CORP (JP) 2017-12-27 EP disclosed
US-20170320981-A1 METALLOCENE COMPOUND, CATALYST FOR OLEFIN POLYMER, METHOD FOR PRODUCING OLEFIN POLYMER, AND OLEFIN POLYMER JAPAN POLYETHYLENE CORPORATION (JP) 2017-11-09 US disclosed
US-9783625-B2 Metallocene compound, catalyst for olefin polymer, method for producing olefin polymer, and olefin polymer JAPAN POLYETHYLENE CORPORATION (JP) 2017-10-10 US disclosed
EP-2963045-B1 METHOD FOR PRODUCING OLEFIN POLYMER WITH A METALLOCENE BASED CATALYST, AND OLEFIN POLYMER JAPAN POLYETHYLENE CORP (JP) 2016-12-21 EP disclosed
EP-3078670-A1 METALLOCENE COMPOUND, CATALYST FOR OLEFIN POLYMER, METHOD FOR PRODUCING OLEFIN POLYMER, AND OLEFIN POLYMER Japan Polyethylene Corporation (JP) 2016-10-12 EP disclosed
US-20160009838-A1 METALLOCENE COMPOUND, CATALYST FOR OLEFIN POLYMER, METHOD FOR PRODUCING OLEFIN POLYMER, AND OLEFIN POLYMER JAPAN POLYETHYLENE CORPORATION (JP) 2016-01-14 US disclosed
EP-2963045-A1 METALLOCENE COMPOUND, CATALYST FOR OLEFIN POLYMER, METHOD FOR PRODUCING OLEFIN POLYMER, AND OLEFIN POLYMER Japan Polyethylene Corporation (JP) 2016-01-06 EP disclosed
US-7297747-B2 Polymerization process and polymer composition EXXONMOBIL CHEMICAL PATENTS INC. (US) 2007-11-20 US disclosed
US-7122498-B2 Metallocenes and catalyst compositions derived therefrom EXXONMOBIL CHEMICAL PATENTS INC. (US) 2006-10-17 US disclosed
US-6870016-B1 Polymerization process and polymer composition EXXONMOBIL CHEMICAL PATENTS INC. (US) 2005-03-22 US disclosed
US-20050059785-A1 Polymerization process and polymer composition HART JAMES R (US) 2005-03-17 US disclosed
US-20050054520-A1 Metallocenes and catalyst compositions derived therefrom EXXONMOBIL CHEMICAL PATENT INC. 2005-03-10 US disclosed
EP-1421090-A2 METALLOCENES AND CATALYST COMPOSITIONS DERIVED THEREFROM Exxonmobil Chemical Patents Inc. (US) 2004-05-26 EP disclosed
WO-2003002583-A2 METALLOCENES AND CATALYST COMPOSITIONS DERIVED THEREFROM EXXONMOBIL CHEMICAL PATENTS INC. (US) 2003-01-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170320981-A1 METALLOCENE COMPOUND, CATALYST FOR OLEFIN POLYMER, METHOD FOR PRODUCING OLEFIN POLYMER, AND OLEFIN POLYMER CPNE4, PIN4, PIN1 FYN 2258/4885CLK4 976/4885DYRK1B 4363/4885
US-20160009838-A1 METALLOCENE COMPOUND, CATALYST FOR OLEFIN POLYMER, METHOD FOR PRODUCING OLEFIN POLYMER, AND OLEFIN POLYMER CPNE4, ALOX12, PIN1 FYN 2629/4885CLK4 1732/4885DYRK1B 4715/4885
US-10005864-B2 Metallocene compound, catalyst for olefin polymer, method for producing olefin polymer, and olefin polymer CPNE4, PPOX, PIN1 FYN 2913/4885CLK4 460/4885DYRK1B 4152/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.