Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 8/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | F7 | P08709 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4918641 | 0.83 | FPR2 (0.47) | FPR2KDM4EALDH1A1SYKADRA2A | |
| SCHEMBL7427231 | 0.72 | ALDH1A1 (0.49) | KDM4EALDH1A1ADRA2AADRA2BADRA2C | |
| SCHEMBL17213665 | 0.72 | KDM4E (0.56) | KDM4EALDH1A1ADRA2AADRA2CHCAR3 | |
| SCHEMBL1206403 | 0.71 | ALDH1A1 (0.48) | FPR2KDM4EALDH1A1ADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL17205819 | 0.71 | KDM4E (0.54) | KDM4EALDH1A1ADRA2AADRA2CHCAR3 | |
| SCHEMBL1663456 | 0.70 | HCAR3 (0.55) | KDM4EALDH1A1HCAR3TDP1 | |
| SCHEMBL23666720 | 0.70 | FPR2 (0.57) | FPR2KDM4EALDH1A1SYKADRA2A | |
| SCHEMBL11259360 | 0.70 | KDM4E (0.58) | KDM4EALDH1A1TDP1 | |
| SCHEMBL15020339 | 0.69 | MDM2 (0.47) | FPR2 | |
| SCHEMBL8207306 | 0.69 | ALDH1A1 (0.45) | KDM4EALDH1A1ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7300934-B2 | Benzamide nitriles | ROCHE PALO ALTO LLC (US) | 2007-11-27 | — | — | US | disclosed |
| EP-1633701-A1 | BENZAMIDE NITRILE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004106285-A1 | BENZAMIDE NITRILE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-12-09 | — | — | WO | disclosed |
| US-20040248949-A1 | Benzamide nitriles | ROCHE PALO ALTO LLC | 2004-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040248949-A1 | Benzamide nitriles | CTSK, CTSS, CMA1 | FPR2 1353/4885KDM4E 3326/4885ALDH1A1 349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.