Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5347713 | 0.81 | CA2 (0.35) | CA2ALDH1A1TSHRTDP1GABRA1 | |
| Hydrochloric Acid SCHEMBL5347487 | 0.77 | MYC (0.37) | CA2ALDH1A1TSHR | |
| SCHEMBL8853306 | 0.77 | CA2 (0.38) | CA2ALDH1A1TSHRTDP1GABRA1 | |
| Hydrochloric Acid SCHEMBL5351373 | 0.75 | HTR2A (0.35) | CA2ALDH1A1TSHRTDP1GABRA1 | |
| Hydrochloric Acid SCHEMBL5352797 | 0.75 | HTR2A (0.35) | CA2ALDH1A1TSHRTDP1GABRA1 | |
| Ethane SCHEMBL8163438 | 0.73 | GPR3 (0.44) | TSHR | |
| Hydrochloric Acid SCHEMBL618216 | 0.73 | GPR3 (0.42) | CA2TSHR | |
| Hydrochloric Acid SCHEMBL8599251 | 0.71 | GPR3 (0.41) | CA2TSHR | |
| Hydrochloric Acid SCHEMBL8378993 | 0.71 | GPR3 (0.41) | CA2TSHR | |
| Hydrochloric Acid SCHEMBL6558603 | 0.71 | DNMT1 (0.40) | ALDH1A1TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230128-B2 | Organometallic fluorenyl compounds, preparations, and use | PHILLIPS POTROLEUM COMPANY (US) | 2007-06-12 | — | — | US | claimed |
| US-20060122344-A1 | Organometallic Fluorenyl Compounds, Preparations, and Use | PHILLIPS PETROLEUM COMPANY (US) | 2006-06-08 | — | — | US | claimed |
| EP-0524624-A2 | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 1993-01-27 | — | — | EP | claimed |
| US-7230128-B2 | Organometallic fluorenyl compounds, preparations, and use | PHILLIPS POTROLEUM COMPANY (US) | 2007-06-12 | — | — | US | disclosed |
| US-20060122344-A1 | Organometallic Fluorenyl Compounds, Preparations, and Use | PHILLIPS PETROLEUM COMPANY (US) | 2006-06-08 | — | — | US | disclosed |
| EP-0773237-B1 | Olefin polymerization catalyst system | MITSUI CHEMICALS INC (JP) | 2004-02-18 | — | — | EP | disclosed |
| US-6420579-B1 | SILYL, GERMANIUM OR TIN RADICALS WITH TITANIUM, ZIRCONIUM, HAFNIUM, VANADIUM, NIOBIUM AND TANTALUM METALS | PHILLIPS PETROLEUM COMPANY | 2002-07-16 | — | — | US | disclosed |
| US-6403734-B1 | POLYMERIZING ALPHA-OLEFIN BY CONTACTING WITH CATALYST SYSTEM COMPRISING BRIDGED FLUORENYL METALLOCENE CONTAINING METAL OF GROUP 4 OR 5 AND SUITABLE COCATALYST | PHILLIPS PETROLEUM COMPANY | 2002-06-11 | — | — | US | disclosed |
| US-6162936-A | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 2000-12-19 | — | — | US | disclosed |
| US-6063725-A | CATALYST COMPRISING ORGANIC TRANSITION METAL COMPOUND AND SEPARATE SUPPORT COMPRISING ORGANIC CARBONYL-CONTAINING COMPOUND AND ORGANIC ALUMINUM OXY COMPOUND | MITSUI CHEMICALS, INC. (JP) | 2000-05-16 | — | — | US | disclosed |
| EP-0773237-A1 | Olefin polymerization catalyst system | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1997-05-14 | — | — | EP | disclosed |
| US-5571880-A | CATALYSTS FOR POLYMERIZATION OF OLEFINS ESPECIALLY TO OBTAIN SYNDIOTACTIC POLYMERS | PHILLIPS PETROLEUM COMPANY (US) | 1996-11-05 | — | — | US | disclosed |
| EP-0666267-A2 | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 1995-08-09 | — | — | EP | disclosed |
| US-5436305-A | Preparing polymer catalysts by reaction of alkali metal alkyl and fluorenyl in solvent | PHILLIPS PETROLEUM COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0524624-A2 | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 1993-01-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122344-A1 | Organometallic Fluorenyl Compounds, Preparations, and Use | HMBS, FDPS, SOD1 | CA2 4431/4885ALDH1A1 790/4885TSHR 4211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.