Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5363358 | 0.81 | ALDH1A1 (0.46) | POLBCYP2C19ALDH1A1LMNAMAPT | |
| SCHEMBL5361045 | 0.80 | ALDH1A1 (0.43) | POLBCYP2D6CYP2C19ALDH1A1LMNA | |
| SCHEMBL5361049 | 0.76 | LMNA (0.50) | POLBCYP2D6CYP2C19ALDH1A1LMNA | |
| SCHEMBL6312418 | 0.73 | HDAC6 (0.41) | POLBALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL5363670 | 0.70 | POLB (0.43) | POLBALDH1A1LMNAMAPT | |
| SCHEMBL3226743 | 0.70 | KCNH2 (0.49) | CYP2D6CYP2C19ALDH1A1LMNAKCNA5 | |
| SCHEMBL5359454 | 0.69 | KDM4E (0.48) | POLBCYP2D6CYP2C19ALDH1A1MAPT | |
| SCHEMBL8011565 | 0.69 | CYP2D6 (0.61) | CYP2D6CYP2C19LMNAHDAC3HDAC4 | |
| SCHEMBL13739154 | 0.69 | CYP2D6 (0.61) | CYP2D6CYP2C19LMNAHDAC3HDAC4 | |
| SCHEMBL9812726 | 0.69 | KCNH2 (0.47) | CYP2D6CYP2C19ALDH1A1LMNAKCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7208481-B2 | Aminodiphosphonate apolipoprotein E modulators | ILEX PRODUCTS, INC. (US) | 2007-04-24 | — | — | US | claimed |
| US-20050075317-A1 | Aminodiphosphonate apolipoprotein e modulators | PHAN HIEU TRUNG (CH) | 2005-04-07 | — | — | US | claimed |
| EP-1482897-A2 | AMINODIPHOSPHONATE APOLIPOPROTEIN E MODULATORS | Ilex Products, Inc. (US) | 2004-12-08 | — | — | EP | claimed |
| WO-2003070169-A2 | AMINODIPHOSPHONATE APOLIPOPROTEIN E MODULATORS | ILEX PRODUCTS, INC. (US) | 2003-08-28 | — | — | WO | claimed |
| US-7208481-B2 | Aminodiphosphonate apolipoprotein E modulators | ILEX PRODUCTS, INC. (US) | 2007-04-24 | — | — | US | disclosed |
| US-20050075317-A1 | Aminodiphosphonate apolipoprotein e modulators | PHAN HIEU TRUNG (CH) | 2005-04-07 | — | — | US | disclosed |
| EP-1482897-A2 | AMINODIPHOSPHONATE APOLIPOPROTEIN E MODULATORS | Ilex Products, Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003070169-A2 | AMINODIPHOSPHONATE APOLIPOPROTEIN E MODULATORS | ILEX PRODUCTS, INC. (US) | 2003-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075317-A1 | Aminodiphosphonate apolipoprotein e modulators | APOB, APOL1, NAPEPLD | POLB 2745/4885CYP2D6 1868/4885CYP2C19 2345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.