Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH3 | Q9ULD8 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | GPR68 | Q15743 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1925175 | 0.82 | KCNH3 (0.51) | KCNH3HTR2CHTR7APPGPR68 | |
| SCHEMBL540957 | 0.77 | KCNH3 (0.86) | KCNH3MAPK1SMN1; SMN2 | |
| SCHEMBL536016 | 0.75 | KCNH3 (0.49) | KCNH3NPC1RAB9AAPPGPR68 | |
| SCHEMBL1280999 | 0.69 | KCNH3 (1.00) | KCNH3 | |
| SCHEMBL1282106 | 0.68 | ALDH1A1 (0.50) | NPC1JAK2RAB9AMAPTADORA2A | |
| SCHEMBL29223873 | 0.66 | CA1 (0.60) | KCNH3HTR2CHTR7APPGPR68 | |
| SCHEMBL535908 | 0.66 | KCNH3 (1.00) | KCNH3 | |
| SCHEMBL28451024 | 0.66 | MAPT (0.54) | NPC1JAK2RAB9AMAPTHTR7 | |
| SCHEMBL15721117 | 0.64 | HTR7 (0.46) | KCNH3HTR2CHTR7ADORA2A | |
| SCHEMBL581128 | 0.63 | MAPT (0.54) | KCNH3NPC1JAK2RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414351-A1 | NOVEL SALT OF 1,3,5-TRIAZINE-2,4,6-TRIAMINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114162-A1 | NOVEL SALT OF 1,3,5-TRIAZINE-2,4,6-TRIAMINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2010-10-07 | — | — | WO | disclosed |