SCHEMBL5375

SCHEMBL5375

CCS(=O)(=O)c1ccc(Br)cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLCG1 P19174 1/20 0.70
PSIP1 O75475 2/20 0.58
GAA P10253 3/20 0.58
CA2 P00918 3/20 0.52
KMT2A Q03164 4/20 0.47
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
SIGMAR1 Q99720 1/20 0.47
CA12 O43570 1/20 0.46
CA9 Q16790 1/20 0.46
CA1 P00915 1/20 0.46
MMP1 P03956 1/20 0.46
MMP2 P08253 1/20 0.46
MMP9 P14780 1/20 0.46
MMP8 P22894 1/20 0.46
MMP13 P45452 1/20 0.46
MEN1 O00255 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10455034 0.87 PSIP1 (0.74) PLCG1PSIP1GAACA2KMT2A
SCHEMBL198253 0.84 PLCG1 (0.61) PLCG1GAACA2KMT2ACYP1A2
SCHEMBL3253487 0.82 PLCG1 (1.00) PLCG1CA2KMT2ACYP1A2CYP3A4
SCHEMBL5104880 0.81 PLCG1 (0.57) PLCG1CA2KMT2ACYP3A4CYP2C9
SCHEMBL9704914 0.80 PLCG1 (0.70) PLCG1CA2KMT2ACYP1A2CYP3A4
SCHEMBL10266897 0.79 PLCG1 (0.55) PLCG1PSIP1GAACA2KMT2A
SCHEMBL14543475 0.79 PLCG1 (0.55) PLCG1CA2KMT2ACYP3A4CYP2C9
SCHEMBL3109600 0.78 PLCG1 (0.67) PLCG1CA2KMT2ACYP1A2CYP3A4
SCHEMBL165340 0.78 PLCG1 (0.67) PLCG1CA2KMT2ACYP1A2CYP3A4
SCHEMBL8488156 0.78 PLCG1 (0.67) PLCG1PSIP1GAACA2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 563 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12479816-B2 20-HETE formation inhibitors University of Pittsburgh—of the Commonwealth System of Higher Education (US) 2025-11-25 US disclosed
US-20240425504-A1 IMIDAZOPYRIDINONE COMPOUND KISSEI PHARMACEUTICAL CO., LTD. (assignee) (JP) 2024-12-26 US disclosed
EP-3808747-B1 IMIDAZOPYRIDINONE COMPOUND KISSEI PHARMACEUTICAL (JP) 2024-12-18 EP disclosed
US-12077531-B2 Imidazopyridinone compound KISSEI PHARMACEUTICAL CO., LTD. (JP) 2024-09-03 US disclosed
CN-113302185-B Benzofuran-6-carboxamide derivatives, preparation method and pharmaceutical application thereof 上海和誉生物医药科技有限公司 2024-04-09 CN disclosed
US-20230382912-A1 PYRAZOLOPYRIDINE DERIVATIVE HAVING GLP-1 RECEPTOR AGONIST EFFECT CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2023-11-30 US disclosed
US-20230382912-A1 PYRAZOLOPYRIDINE DERIVATIVE HAVING GLP-1 RECEPTOR AGONIST EFFECT CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2023-11-30 US disclosed
US-11814381-B2 Pyrazolopyridine derivative having GLP-1 receptor agonist effect CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2023-11-14 US disclosed
US-11814381-B2 Pyrazolopyridine derivative having GLP-1 receptor agonist effect CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2023-11-14 US disclosed
CN-112689637-B Imidazopyridone compounds 橘生药品工业株式会社 2023-11-10 CN disclosed
US-6340759-B1 ANTISPASMODIC AGENTS EISAI CO., LTD. (JP) 2002-01-22 US disclosed
EP-1020445-A1 FUSED PYRIDINE DERIVATIVES Eisai Co., Ltd. (JP) 2000-07-19 EP disclosed
CN-1042539-C 11,21-bisphenyl-19-norpregnane derivatives AKZO NOBEL NV (NL) 1999-03-17 CN disclosed
EP-0683172-B1 11,21-Bisphenyl-19-norpregnane derivatives AKZO NOBEL NV (NL) 1997-08-13 EP disclosed
US-5620966-A ANTIGLUOCORTICOID ACTIVITY AKZO NOBEL N.V. (NL) 1997-04-15 US disclosed
CN-1126727-A 11,21-bisphenyl-19-norpregnane derivatives AKZO NOBEL NV (NL) 1996-07-17 CN disclosed
EP-0683172-A1 11,21-Bisphenyl-19-norpregnane derivatives Akzo Nobel N.V. (NL) 1995-11-22 EP disclosed
EP-0412387-B1 Diarylacetylenes, their process and use BASF AG (DE) 1993-11-24 EP disclosed
US-5087637-A Skin disorders BASF AKTIENGESELLSCHAFT (DE) 1992-02-11 US disclosed
EP-0412387-A2 Diarylacetylenes, their process and use BASF Aktiengesellschaft (DE) 1991-02-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230382912-A1 PYRAZOLOPYRIDINE DERIVATIVE HAVING GLP-1 RECEPTOR AGONIST EFFECT GLP1R, GPR119, GIPR PLCG1 1595/4885PSIP1 333/4885GAA 3422/4885
US-12077531-B2 Imidazopyridinone compound EGLN3, DHPS, EGLN2 PLCG1 3942/4885PSIP1 623/4885GAA 1889/4885
US-12479816-B2 20-HETE formation inhibitors CYP4A22, ALOX5, ALOX15 PLCG1 1871/4885PSIP1 3791/4885GAA 1379/4885
US-20240425504-A1 IMIDAZOPYRIDINONE COMPOUND EGLN3, DHPS, EGLN2 PLCG1 3942/4885PSIP1 623/4885GAA 1889/4885
US-11814381-B2 Pyrazolopyridine derivative having GLP-1 receptor agonist effect GLP1R, GPR119, GIPR PLCG1 758/4885PSIP1 430/4885GAA 3870/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.