Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9923550 | 0.89 | L3MBTL1 (0.49) | L3MBTL1MAPTHPGDRAB9ANPC1 | |
| SCHEMBL11428548 | 0.88 | HTR2A (0.50) | L3MBTL1MAPTHPGDRAB9ANPC1 | |
| SCHEMBL10937945 | 0.83 | CYP1A2 (0.53) | L3MBTL1CYP2C9CYP2C19ALDH1A1ALOX12 | |
| SCHEMBL13799708 | 0.82 | TTR (0.47) | L3MBTL1CYP2C9CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL5371133 | 0.81 | SLC6A4 (0.45) | L3MBTL1MAPTHPGDRAB9ANPC1 | |
| SCHEMBL554766 | 0.81 | TEAD4 (0.57) | L3MBTL1MAPTHPGDCYP2C9CYP2C19 | |
| SCHEMBL18708752 | 0.81 | ACHE (0.46) | L3MBTL1MAPTHPGDRAB9ACYP2C9 | |
| SCHEMBL13581464 | 0.81 | MAOB (0.46) | L3MBTL1MAPTHPGDRAB9ANPC1 | |
| SCHEMBL10544322 | 0.81 | L3MBTL1 (0.44) | L3MBTL1MAPTHPGDRAB9ANPC1 | |
| SCHEMBL3793518 | 0.80 | LTA4H (0.50) | MAPTCYP2C9CYP2C19ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0008735-A1 | Process for the preparation of diphenyl ether carboxylic acids | BAYER AG (DE) | 1980-03-19 | — | — | EP | claimed |
| EP-1608633-B1 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS I FOR TREATING HIV MEDIATED DISEASES | HOFFMANN LA ROCHE (CH) | 2016-04-20 | — | — | EP | disclosed |
| EP-1608633-B1 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS I FOR TREATING HIV MEDIATED DISEASES | HOFFMANN LA ROCHE (CH) | 2016-04-20 | — | — | EP | disclosed |
| CN-100588650-C | Non-nucleoside reverse transcriptase inhibitors I for the treatment of HIV mediated diseases | HOFFMANN LA ROCHE | 2010-02-10 | — | — | CN | disclosed |
| CN-100469769-C | Benzyl-pyridazinons as reverse transcriptase inhibitors | ROCHE PALO ALTO LLC (CH) | 2009-03-18 | — | — | CN | disclosed |
| US-7348345-B2 | Nonnucleoside reverse transcriptase inhibitors | ROCHE PALO ALTO LLC (US) | 2008-03-25 | — | — | US | disclosed |
| US-7348345-B2 | Nonnucleoside reverse transcriptase inhibitors | ROCHE PALO ALTO LLC (US) | 2008-03-25 | — | — | US | disclosed |
| US-20070179157-A1 | Nonnucleoside reverse transcriptase inhibitors | DUNN JAMES P | 2007-08-02 | — | — | US | disclosed |
| US-20070179157-A1 | Nonnucleoside reverse transcriptase inhibitors | DUNN JAMES P | 2007-08-02 | — | — | US | disclosed |
| US-7208509-B2 | Non-nucleoside reverse transcriptase inhibitors | ROCHE PALO ALTO LLC (US) | 2007-04-24 | — | — | US | disclosed |
| US-20040198736-A1 | Non-nucleoside reverse transcriptase inhibitors | ROCHE PALO ALTO LLC | 2004-10-07 | — | — | US | disclosed |
| WO-2004085411-A1 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS I FOR TREATING HIV MEDIATED DISEASES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-10-07 | — | — | WO | disclosed |
| US-20040192704-A1 | Non-nucleoside reverse transcriptase inhibitors | ROCHE PALO ALTO LLC | 2004-09-30 | — | — | US | disclosed |
| EP-0045423-B1 | PROCESS FOR THE ALPHA-HALOGENATION OF POSSIBLY SUBSTITUTED METHYL AROMATICS | BAYER AG (DE) | 1984-02-22 | — | — | EP | disclosed |
| EP-0030333-B1 | ALKYLDIPHENYL-ETHER SULFONIC ACID HYDRAZIDES, THEIR PRODUCTION AND USE AS BLOWING AGENTS | BAYER AG (DE) | 1983-03-09 | — | — | EP | disclosed |
| US-4329499-A | Alkyldiphenyl ether-sulphonic acid hydrazides, their preparation and their use as blowing agents | BAYER AKTIENGESELLSCHAFT (DE) | 1982-05-11 | — | — | US | disclosed |
| EP-0045423-A1 | Process for the alpha-halogenation of possibly substituted methyl aromatics | BAYER AG (DE) | 1982-02-10 | — | — | EP | disclosed |
| EP-0030333-A1 | Alkyldiphenyl-ether sulfonic acid hydrazides, their production and use as blowing agents | BAYER AG (DE) | 1981-06-17 | — | — | EP | disclosed |
| US-4209584-A | COATING BY TANDEM GRAVURE, DIFFUSION OF HARDENING AGENT INTO HYDROPHILIC COLLOIDS | EASTMAN KODAK COMPANY (US) | 1980-06-24 | — | — | US | disclosed |
| EP-0008735-A1 | Process for the preparation of diphenyl ether carboxylic acids | BAYER AG (DE) | 1980-03-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192704-A1 | Non-nucleoside reverse transcriptase inhibitors | POLR1A, POLA1, REV1 | L3MBTL1 1644/4885MAPT 1407/4885HPGD 818/4885 |
| US-20040198736-A1 | Non-nucleoside reverse transcriptase inhibitors | POLR1A, POLR2A, POLR2E | L3MBTL1 2049/4885MAPT 1798/4885HPGD 983/4885 |
| US-20070179157-A1 | Nonnucleoside reverse transcriptase inhibitors | RRM2, RRM2B, SAMHD1 | L3MBTL1 1581/4885MAPT 2936/4885HPGD 1312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.