Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Diphenylether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 7/20 | 0.92 |
| ▸ | TSHR | P16473 | 1/20 | 0.92 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.63 |
| ▸ | BAX | Q07812 | 1/20 | 0.63 |
| ▸ | MAOA | P21397 | 1/20 | 0.63 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.50 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylether SCHEMBL363273 | 1.00 | LTA4H (0.92) | LTA4HTSHRNR1H2BAXMAOA | |
| Diphenylether SCHEMBL27530955 | 1.00 | LTA4H (0.92) | LTA4HTSHRNR1H2BAXMAOA | |
| Diphenylether SCHEMBL11777679 | 1.00 | LTA4H (0.92) | LTA4HTSHRNR1H2BAXMAOA | |
| Diphenylether SCHEMBL11775858 | 1.00 | LTA4H (0.92) | LTA4HTSHRNR1H2BAXMAOA | |
| Diphenylether SCHEMBL11777927 | 1.00 | LTA4H (0.92) | LTA4HTSHRNR1H2BAXMAOA | |
| Diphenylether SCHEMBL28256347 | 0.96 | LTA4H (0.86) | LTA4HTSHRNR1H2BAXMAOA | |
| Diphenylether SCHEMBL1176694 | 0.96 | LTA4H (0.86) | LTA4HTSHRNR1H2BAXMAOA | |
| Diphenylether SCHEMBL7031694 | 0.96 | LTA4H (0.86) | LTA4HTSHRNR1H2BAXMAOA | |
| Diphenylether SCHEMBL9061108 | 0.96 | LTA4H (1.00) | LTA4HTSHRNR1H2BAXMAOA | |
| Diphenylether SCHEMBL4950525 | 0.96 | LTA4H (1.00) | LTA4HTSHRNR1H2BAXMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103619909-B | The manufacture method of polyphenyl ether ether ketone | TORAY INDUSTRIES, INC. (JP) | 2016-05-11 | — | — | CN | claimed |
| EP-2497985-A1 | A mixer group for hydraulic apparatus, in particular taps, mixers, shower heads and/or the like and hydraulic apparatus provided with said mixer group | Cerutti, Silvano (IT) | 2012-09-12 | — | — | EP | claimed |
| EP-2415936-A2 | A spacer element for hydraulic apparatus | Cerutti, Silvano (IT) | 2012-02-08 | — | — | EP | claimed |
| CN-106909026-B | A kind of anti-corrosion agent composition that can directly describe exposure image and resist layer laminate | 苏州福斯特光伏材料有限公司 | 2019-11-22 | — | — | CN | disclosed |
| CN-107656334-A | Polyvinyl alcohol film | 株式会社可乐丽 | 2018-02-02 | — | — | CN | disclosed |
| CN-107550920-A | Angle conjunctiva protective agent or angle conjunctiva obstacle inhibitor | 东洋精糖株式会社 | 2018-01-09 | — | — | CN | disclosed |
| CN-104870519-B | The manufacture method of ring type polyphenylene ether ether one compositions and wire polyphenylene ether ether ketone, the manufacture method of polyphenylene ether ether ketone | 东丽株式会社 | 2017-11-24 | — | — | CN | disclosed |
| CN-104204045-B | Polyvinyl alcohol polymer film | 株式会社可乐丽 | 2017-11-24 | — | — | CN | disclosed |
| CN-107112536-A | Carbon material and nonaqueous secondary battery using same | 三菱化学株式会社 | 2017-08-29 | — | — | CN | disclosed |
| CN-103619909-B | The manufacture method of polyphenyl ether ether ketone | TORAY INDUSTRIES, INC. (JP) | 2016-05-11 | — | — | CN | disclosed |
| CN-103814019-A | Method for recovering cyclic polyphenylene ether ether ketone composition and method for producing polyphenylene ether ether ketone using same | TORAY INDUSTRIES | 2014-05-21 | — | — | CN | disclosed |
| US-6689825-B1 | THERMOPLASTIC RESIN, RESORCINOL DIPHENYL PHOSPHATE AND ADDITIVE BLEND OF MELAMINE POLYPHOSPHATE AND FERROCENE | GENERAL ELECTRIC COMPANY | 2004-02-10 | — | — | US | disclosed |
| EP-1276814-A1 | HIGH FLOW POLYPHENYLENE ETHER FORMULATIONS WITH DENTRITIC POLYMERS | GENERAL ELECTRIC COMPANY (US) | 2003-01-22 | — | — | EP | disclosed |
| US-20020151652-A1 | High flow polyphenylene ether formulations with dendritic polymers | CITIBANK, N.A., AS COLLATERAL AGENT | 2002-10-17 | — | — | US | disclosed |
| US-6414084-B1 | COMPOSITION COMPRISING POLYPHENYLENE ETHER RESIN AND DENDRITIC POLYMER HAVING STARBURST CONFIGURATION AND COMPRISING POLYESTER BRANCHING UNITS BOUND TO CORE | GENERAL ELECTRIC COMPANY | 2002-07-02 | — | — | US | disclosed |
| WO-2001079352-A1 | HIGH FLOW POLYPHENYLENE ETHER FORMULATIONS WITH DENTRITIC POLYMERS | GENERAL ELECTRIC COMPANY (US) | 2001-10-25 | — | — | WO | disclosed |
| US-5405868-A | Treating skin disorders | GOUPIL JEAN-JACQUES (FR) | 1995-04-11 | — | — | US | disclosed |
| US-5360816-A | ORALLY ADMINISTERING 5-METHOXY-PSORALEN TO A PATIENT AND THEN EXPOSING PATIENT TO ULTRAVIOLET RADIATION | GOUPIL JEAN JACQUES (FR) | 1994-11-01 | — | — | US | disclosed |
| US-4429138-A | MULTISTEP, FROM PHLOROGLUCINOL | GOUPIL JEAN JACQUES (FR) | 1984-01-31 | — | — | US | disclosed |
| US-4207266-A | CARBON TETRALIDE, HYDROGEN FLUORIDE, LEWIS ACID AD AROMATIC HYDROCARBON | ROHM AND HAAS COMPANY (US) | 1980-06-10 | — | — | US | disclosed |