Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Diphenylether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 7/20 | 0.92 |
| ▸ | TSHR | P16473 | 1/20 | 0.92 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.63 |
| ▸ | BAX | Q07812 | 1/20 | 0.63 |
| ▸ | MAOA | P21397 | 1/20 | 0.63 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.50 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylether SCHEMBL27530955 | 1.00 | LTA4H (0.92) | LTA4HTSHRNR1H2BAXMAOA | |
| Diphenylether SCHEMBL538765 | 1.00 | LTA4H (0.92) | LTA4HTSHRNR1H2BAXMAOA | |
| Diphenylether SCHEMBL11777679 | 1.00 | LTA4H (0.92) | LTA4HTSHRNR1H2BAXMAOA | |
| Diphenylether SCHEMBL11775858 | 1.00 | LTA4H (0.92) | LTA4HTSHRNR1H2BAXMAOA | |
| Diphenylether SCHEMBL11777927 | 1.00 | LTA4H (0.92) | LTA4HTSHRNR1H2BAXMAOA | |
| Diphenylether SCHEMBL28256347 | 0.96 | LTA4H (0.86) | LTA4HTSHRNR1H2BAXMAOA | |
| Diphenylether SCHEMBL1176694 | 0.96 | LTA4H (0.86) | LTA4HTSHRNR1H2BAXMAOA | |
| Diphenylether SCHEMBL7031694 | 0.96 | LTA4H (0.86) | LTA4HTSHRNR1H2BAXMAOA | |
| Diphenylether SCHEMBL9061108 | 0.96 | LTA4H (1.00) | LTA4HTSHRNR1H2BAXMAOA | |
| Diphenylether SCHEMBL4950525 | 0.96 | LTA4H (1.00) | LTA4HTSHRNR1H2BAXMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585536-A2 | CURABLE RESIN COMPOSITIONS | Dow Global Technologies LLC (US) | 2013-05-01 | — | — | EP | claimed |
| WO-2012009120-A2 | CURABLE RESIN COMPOSITIONS | DOW GLOBAL TECHNOLOGIES LLC (US) | 2012-01-19 | — | — | WO | claimed |
| WO-2024101068-A1 | RESIN COMPOSITION, ADHESIVE COMPOSITION, LAYERED PRODUCT WITH ADHESIVE LAYER, COVERLAY FILM, BONDING SHEET, ELECTROMAGNETIC WAVE SHIELDING MATERIAL, COMPOSITE MATERIAL, POLYURETHANE, AND COMPOSITION | 東亞合成株式会社 | 2024-05-16 | — | — | WO | disclosed |
| CN-117936859-A | Preparation method and application of polyquinoxaline high-temperature proton exchange membrane | 中国科学院山西煤炭化学研究所 | 2024-04-26 | — | — | CN | disclosed |
| CN-115521435-B | Resin, curable resin composition, cured product, insulating material, and resist member | DIC株式会社 | 2024-02-09 | — | — | CN | disclosed |
| US-11873443-B2 | Composition and production method of same, and dispersing agent | NIPPON PAPER INDUSTRIES CO., LTD. (JP) | 2024-01-16 | — | — | US | disclosed |
| CN-116940610-A | Curable resin composition, active energy ray-curable resin composition, cured product, and article | DIC株式会社 | 2023-10-24 | — | — | CN | disclosed |
| CN-116601724-A | Active energy ray-curable resin composition, cured product, insulating material, and resist member | DIC株式会社 | 2023-08-15 | — | — | CN | disclosed |
| CN-116082630-A | Alcoholic hydroxyl group-terminated polyphenyl ether polyol and preparation method thereof | 大连理工大学 | 2023-05-09 | — | — | CN | disclosed |
| CN-115895236-A | Halogen-free flame-retardant thermoplastic polyurethane elastomer and preparation method thereof | 江苏湘园化工有限公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-115857291-A | Electrophotographic photoreceptor, process cartridge, and image forming apparatus | 富士胶片商业创新有限公司 | 2023-03-28 | — | — | CN | disclosed |
| CN-104394986-A | Phosphinyl guanidine compounds, metal salt complexes, catalyst systems, and their use to oligomerize or polymerize olefins | CHEVRON PHILLIPS CHEMICAL CO | 2015-03-04 | — | — | CN | disclosed |
| US-20130150605-A1 | Preparation of Transition Metal Carboxylates | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2013-06-13 | — | — | US | disclosed |
| CN-101528222-A | Methods and compositions for diagnostic and therapeutic targeting of COX-2 | UNIV VANDERBILT (US) | 2009-09-09 | — | — | CN | disclosed |
| CN-101456962-A | High-content red phosphorus flame-retardant master batch | HUACHANG HUANG (CN) | 2009-06-17 | — | — | CN | disclosed |
| US-6965001-B2 | Organic-inorganic hybrid polymer materials with compositional gradient, and processes for preparing the same | ORIENT CHEMICAL INDUSTRIES, LTD. (JP) | 2005-11-15 | — | — | US | disclosed |
| EP-0972809-B1 | Organic-inorganic hybrid polymer materials with compositional gradient, and processes for preparing the same | ORIENT CHEMICAL IND (JP) | 2004-10-06 | — | — | EP | disclosed |
| US-20020122891-A1 | Organic-inorganic hybrid polymer materials with compositional gradient, and processes for preparing the same | ARAKAWA MOTOOMI (JP) | 2002-09-05 | — | — | US | disclosed |
| US-6395341-B1 | ORGANIC POLYMER AND METAL ALKOXIDE | ORIENT CHEMICAL INDUSTRIES, LTD. (JP) | 2002-05-28 | — | — | US | disclosed |
| EP-0972809-A2 | Organic-inorganic hybrid polymer materials with compositional gradient, and processes for preparing the same | ORIENT CHEMICAL INDUSTRIES, LTD. (JP) | 2000-01-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150605-A1 | Preparation of Transition Metal Carboxylates | ACMSD, AP1M1, CA1 | MEN1 803/4885LTA4H 4302/4885TSHR 4038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.