SCHEMBL5406439

SCHEMBL5406439

c1cnc2sc3cnccc3c2c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.42
LIMK1 P53667 3/20 0.39
IKBKB O14920 2/20 0.39
CHUK O15111 2/20 0.39
CLK1 P49759 2/20 0.39
CDC7 O00311 1/20 0.39
DBF4 Q9UBU7 1/20 0.39
IKBKE Q14164 3/20 0.38
PDPK1 O15530 2/20 0.38
TGFBR1 P36897 2/20 0.38
TBK1 Q9UHD2 3/20 0.36
KDM4E B2RXH2 3/20 0.36
HPGD P15428 3/20 0.36
ALDH1A1 P00352 2/20 0.36
GLA P06280 1/20 0.36
GAA P10253 1/20 0.36
CASP1 P29466 1/20 0.36
HTT P42858 1/20 0.36
CASP7 P55210 1/20 0.36
NCOA1 Q15788 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24624429 0.88 LIMK1 (0.37) LMNALIMK1IKBKBCHUKCLK1
SCHEMBL15836005 0.87 PIK3CA (0.35) LMNALIMK1IKBKBCHUKCLK1
SCHEMBL11884989 0.85 LIMK1 (0.39) LMNALIMK1IKBKBCHUKCLK1
SCHEMBL3378060 0.80 GPR3 (0.54) LMNALIMK1IKBKBCHUKCLK1
SCHEMBL30376713 0.80 GPR3 (0.54) LMNALIMK1IKBKBCHUKCLK1
SCHEMBL19578845 0.80 LIMK1 (0.37) LIMK1CLK1CDC7DBF4KDM4E
SCHEMBL23766631 0.80 CLK1 (0.35) LMNALIMK1CLK1CDC7DBF4
SCHEMBL23766609 0.79 LIMK1 (0.40) LMNALIMK1IKBKBCHUKCLK1
SCHEMBL24270400 0.78 KDM4E (0.36) LIMK1TBK1KDM4EHPGDALDH1A1
SCHEMBL4903332 0.77 LIMK1 (0.50) LMNALIMK1IKBKBCHUKCLK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230357188-A1 PHENANTHRENE ORGANIC COMPOUND AND USE THEREOF WUHAN TIANMA MICROELECTRONICS CO., LTD. (CN) 2023-11-09 US disclosed
US-20230357188-A1 PHENANTHRENE ORGANIC COMPOUND AND USE THEREOF WUHAN TIANMA MICROELECTRONICS CO., LTD. (CN) 2023-11-09 US disclosed
US-11758807-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION 2023-09-12 US disclosed
US-11744151-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2023-08-29 US disclosed
US-11744151-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2023-08-29 US disclosed
US-20230151020-A1 HETEROCYCLIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE WUHAN TIANMA MICROELECTRONICS CO., LTD. (CN) 2023-05-18 US disclosed
US-20230151020-A1 HETEROCYCLIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE WUHAN TIANMA MICROELECTRONICS CO., LTD. (CN) 2023-05-18 US disclosed
US-20220223794-A1 HETEROCYCLIC COMPOUND CONTAINING HETEROATOM SUBSTITUTED FLUORENE AND APPLICATION THEREOF Wuhan Tianma Microelectronics Co., Ltd. Shanghai Branch (CN) 2022-07-14 US disclosed
US-20210257563-A1 Organic Electroluminescent Materials and Devices UNIVERSAL DISPLAY CORPORATION 2021-08-19 US disclosed
US-9997712-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2018-06-12 US disclosed
US-8415031-B2 Electron transporting compounds UNIVERSAL DISPLAY CORPORATION (US) 2013-04-09 US disclosed
US-20120187381-A1 Electron Transporting Compounds UNIVERSAL DISPLAY CORPORATION (US) 2012-07-26 US disclosed
US-8227801-B2 Bicarbzole containing compounds for OLEDs UNIVERSAL DISPLAY CORPORATION (US) 2012-07-24 US disclosed
US-20110260138-A1 BICARBZOLE CONTAINING COMPOUNDS FOR OLEDS UNIVERSAL DISPLAY CORPORATION (US) 2011-10-27 US disclosed
US-7291733-B2 Substituted tricyclic heterocycles and their uses BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2007-11-06 US disclosed
US-20050101601-A1 Substituted tricyclic heterocycles and their uses BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2005-05-12 US disclosed
US-6403606-B1 ANTIINFLAMMATORY, ANTIARTHRITIS, A DRUG FOR INHIBITING BONE RESORPTION, IMMUNOSUPPRESSANT TAKEDA CHEMICAL INDUSTRIES LTD. (JP) 2002-06-11 US disclosed
US-6046189-A ANTI-INFLAMMATORY DRUG, PARTICULARLY, A DRUG FOR PREVENTING OR TREATING ARTHRITIS, A DRUG FOR INHIBITING BONE RESORPTION, IMMUNOSUPPRESSANT TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-04-04 US disclosed
EP-0900223-A1 THIENOPYRIDINE DERIVATIVES AND THEIR USE Takeda Chemical Industries, Ltd. (JP) 1999-03-10 EP disclosed
WO-1997040050-A1 THIENOPYRIDINE DERIVATIVES AND THEIR USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-10-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220223794-A1 HETEROCYCLIC COMPOUND CONTAINING HETEROATOM SUBSTITUTED FLUORENE AND APPLICATION THEREOF NR0B2, FPR3, NPR3 LMNA 2493/4885LIMK1 3355/4885IKBKB 4165/4885
US-20230357188-A1 PHENANTHRENE ORGANIC COMPOUND AND USE THEREOF AHR, ORAI3, WNT3 LMNA 502/4885LIMK1 455/4885IKBKB 2814/4885
US-11744151-B2 Organic electroluminescent materials and devices OCIAD2, OCIAD1, JUND LMNA 4146/4885LIMK1 1839/4885IKBKB 4445/4885
US-20050101601-A1 Substituted tricyclic heterocycles and their uses LTC4S, NQO1, CBR3 LMNA 2396/4885LIMK1 4013/4885IKBKB 178/4885
US-20210257563-A1 Organic Electroluminescent Materials and Devices OCIAD2, OCIAD1, OSBP LMNA 4519/4885LIMK1 1588/4885IKBKB 4808/4885
US-20230151020-A1 HETEROCYCLIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE OCIAD1, OCIAD2, EHD1 LMNA 1600/4885LIMK1 351/4885IKBKB 3192/4885
US-20120187381-A1 Electron Transporting Compounds SLC19A2, ABCB7, SLCO2B1 LMNA 3787/4885LIMK1 4565/4885IKBKB 4305/4885
US-20110260138-A1 BICARBZOLE CONTAINING COMPOUNDS FOR OLEDS OCIAD1, OCIAD2, BRD7 LMNA 4550/4885LIMK1 4498/4885IKBKB 4142/4885
US-11758807-B2 Organic electroluminescent materials and devices GLRA3, ESRRG, GLRA1 LMNA 2206/4885LIMK1 2662/4885IKBKB 3614/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.