Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | TOP1 | P11387 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2700124 | 0.86 | NPC1 (0.63) | HSD17B10HPGDKDM4EALDH1A1LMNA | |
| SCHEMBL28652342 | 0.82 | HSD17B10 (0.70) | HSD17B10HPGDKDM4EALDH1A1LMNA | |
| SCHEMBL11314930 | 0.80 | NPC1 (0.62) | HSD17B10HPGDKDM4EALDH1A1LMNA | |
| SCHEMBL31471693 | 0.80 | MAOB (0.57) | HSD17B10HPGDKDM4EALDH1A1LMNA | |
| SCHEMBL14096441 | 0.77 | ALDH1A1 (0.60) | HPGDKDM4EALDH1A1LMNAMAPK1 | |
| SCHEMBL3690385 | 0.77 | HPGD (0.77) | HSD17B10HPGDKDM4EALDH1A1LMNA | |
| SCHEMBL13290719 | 0.76 | NPC1 (0.68) | HSD17B10HPGDKDM4EALDH1A1LMNA | |
| SCHEMBL742810 | 0.75 | ACHE (0.62) | HSD17B10HPGDKDM4EALDH1A1LMNA | |
| SCHEMBL31229899 | 0.75 | ACHE (0.62) | HSD17B10HPGDKDM4EALDH1A1LMNA | |
| SCHEMBL4070408 | 0.75 | RAB9A (0.59) | HPGDKDM4EALDH1A1MAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070111989-A1 | Novel diazabicyclononene derivatives and use | ACTELION PHARMACEUTICALS LTD. (CH) | 2007-05-17 | — | — | US | disclosed |
| EP-1692133-A1 | DIAZABICYCLONONENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS | Actelion Pharmaceuticals Ltd. (CH) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005054243-A1 | DIAZABICYCLONONENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2005-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070111989-A1 | Novel diazabicyclononene derivatives and use | REN, ACE, AGTR1 | HSD17B10 185/4885HPGD 1080/4885KDM4E 1488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.