SCHEMBL5437372

SCHEMBL5437372

CNC(=O)c1cc(-c2c(Cl)cccc2Cl)ccc1F

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.50
HTR1A P08908 1/20 0.43
DRD2 P14416 1/20 0.43
HTR2A P28223 1/20 0.43
CNR1 P21554 1/20 0.43
PIK3CA P42336 1/20 0.41
MTOR P42345 1/20 0.41
CHRNA7 P36544 2/20 0.41
NUDT1 P36639 2/20 0.40
ACLY P53396 1/20 0.40
ALDH1A1 P00352 1/20 0.40
RAB9A P51151 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
PDK2 Q15119 1/20 0.39
KAT6A Q92794 1/20 0.39
DHODH Q02127 1/20 0.39
FABP3 P05413 1/20 0.39
FABP4 P15090 1/20 0.39
MET P08581 1/20 0.39
DOT1L Q8TEK3 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5427243 0.81 ALDH1A1 (0.47) GAACNR1ACLYALDH1A1RAB9A
SCHEMBL5419835 0.81 FABP4 (0.47) CNR1ACLYALDH1A1FABP3FABP4
SCHEMBL20056601 0.79 HSD17B1 (0.52) GAANUDT1ACLYRAB9ASMN1; SMN2
SCHEMBL17481527 0.77 GAA (0.58) GAANUDT1ALDH1A1RAB9ASMN1; SMN2
SCHEMBL5423712 0.75 HDAC8 (0.54) CNR1ALDH1A1PDK2KAT6ADOT1L
SCHEMBL24311514 0.73 GAA (0.56) GAAHTR1ADRD2HTR2AALDH1A1
SCHEMBL20652569 0.72 GAA (0.50) GAANUDT1RAB9ASMN1; SMN2
SCHEMBL7133296 0.72 CES2 (0.61) GAANUDT1ALDH1A1RAB9A
SCHEMBL879116 0.71 GAA (0.58) GAANUDT1ALDH1A1RAB9AKAT6A
SCHEMBL5284858 0.71 POLB (0.50) GAANUDT1ALDH1A1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070135497-A1 Biphenyl derivative or its salt, and pesticide containing it as an active ingredient ISHIHARA SANGYO KAISHA LTD. (JP) 2007-06-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070135497-A1 Biphenyl derivative or its salt, and pesticide containing it as an active ingredient DDT, HCN1, HCN2 GAA 4273/4885HTR1A 2893/4885DRD2 1332/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.