Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 6/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13931143 | 0.88 | MAPT (0.40) | MAPTKDM4ECYP19A1BACE1ALDH1A1 | |
| SCHEMBL10992191 | 0.82 | L3MBTL1 (0.42) | MAPTKDM4EABCB1PDE3BPDE3A | |
| SCHEMBL4187132 | 0.78 | GSTP1 (0.53) | MAPTKDM4ECYP19A1BACE1PDE3B | |
| SCHEMBL1471837 | 0.74 | MAPT (0.51) | MAPTKDM4ETHRBPDE4APDE4B | |
| SCHEMBL11000171 | 0.73 | AHR (0.43) | MAPTKDM4ETHRBHSP90AA1RAD51 | |
| SCHEMBL10994041 | 0.72 | RGS4 (0.53) | MAPTKDM4EHSP90AA1BACE1ALDH1A1 | |
| SCHEMBL4187631 | 0.71 | DAPK3 (0.39) | MAPTBACE1PDE3BPDE3ALMNA | |
| SCHEMBL13931139 | 0.71 | PTGS2 (0.37) | MAPTKDM4ECYP19A1MEN1ALDH1A1 | |
| SCHEMBL13931141 | 0.71 | TUBB4A (0.43) | MAPTABCB1MEN1ALDH1A1KMT2A | |
| SCHEMBL6003729 | 0.70 | SIGMAR1 (0.38) | MAPTKDM4EHSP90AA1BACE1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070149600-A1 | Substituted octahydroisoindoles | BIOVITRUM AB (SE) | 2007-06-28 | — | — | US | disclosed |
| US-20070149600-A1 | Substituted octahydroisoindoles | BIOVITRUM AB (SE) | 2007-06-28 | — | — | US | disclosed |
| US-20070149600-A1 | Substituted octahydroisoindoles | BIOVITRUM AB (SE) | 2007-06-28 | — | — | US | disclosed |
| WO-2006114402-A1 | SUBSTITUTED OCTAHYDROISOINDOLES AS ANTAGONISTS OF MELANIN CONCENTRATING HORMONE RECEPTOR 1 (MCH1R) | BIOVITRUM AB (PUBL) (SE) | 2006-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149600-A1 | Substituted octahydroisoindoles | MCHR1, HCRTR1, NPY1R | MAPT 689/4885KDM4E 3695/4885THRB 171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.