Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 10/20 | 0.61 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.50 |
| ▸ | DHODH | Q02127 | 1/20 | 0.50 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2920377 | 0.86 | DGAT1 (0.56) | KIF11CASP1DGAT1GPR52KDM4E | |
| SCHEMBL4464473 | 0.85 | KIF11 (0.55) | KIF11DHODHKDM4EALDH1A1HPGD | |
| SCHEMBL17732182 | 0.83 | KIF11 (0.54) | KIF11CASP1ALDH1A1TRPV1APP | |
| SCHEMBL17732180 | 0.83 | KIF11 (0.54) | KIF11KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5422686 | 0.83 | KIF11 (0.58) | KIF11DGAT1 | |
| SCHEMBL30131431 | 0.81 | IKBKB (0.61) | DGAT1DHODH | |
| SCHEMBL13927718 | 0.81 | IKBKB (0.61) | DGAT1DHODH | |
| SCHEMBL8336975 | 0.80 | CHUK (0.66) | KIF11CASP1DHODHCSF1RPARP1 | |
| SCHEMBL17688761 | 0.80 | CFTR (0.57) | KIF11KDM4ETRPV1APP | |
| SCHEMBL23367143 | 0.78 | CASP1 (0.49) | KIF11CASP1DHODHPARP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070265345-A1 | Novel Biphenyl Compounds And Their Use | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-15 | — | — | US | claimed |
| EP-1778214-A2 | NOVEL BIPHENYL COMPOUNDS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-02 | — | — | EP | claimed |
| WO-2006020358-A2 | NOVEL BIPHENYL COMPOUNDS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2006-02-23 | — | — | WO | claimed |
| CN-106795167-B | Pesticidally active tetracyclic heterocyclic derivatives with sulfur-containing substituents | 先正达参股股份有限公司 | 2021-02-09 | — | — | CN | disclosed |
| US-10544148-B2 | Pesticidally active tetracyclic heterocyclic derivatives with sulphur containing substituents | SYNGENTA PARTICIPATIONS AG (CH) | 2020-01-28 | — | — | US | disclosed |
| US-10544148-B2 | Pesticidally active tetracyclic heterocyclic derivatives with sulphur containing substituents | SYNGENTA PARTICIPATIONS AG (CH) | 2020-01-28 | — | — | US | disclosed |
| EP-3207044-B1 | PESTICIDALLY ACTIVE TETRACYCLIC HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS | SYNGENTA PARTICIPATIONS AG (CH) | 2018-07-25 | — | — | EP | disclosed |
| EP-3207044-B1 | PESTICIDALLY ACTIVE TETRACYCLIC HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS | SYNGENTA PARTICIPATIONS AG (CH) | 2018-07-25 | — | — | EP | disclosed |
| US-20170240554-A1 | PESTICIDALLY ACTIVE TETRACYCLIC HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS | SYNGENTA PARTICIPATIONS AG (CH) | 2017-08-24 | — | — | US | disclosed |
| US-20170240554-A1 | PESTICIDALLY ACTIVE TETRACYCLIC HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS | SYNGENTA PARTICIPATIONS AG (CH) | 2017-08-24 | — | — | US | disclosed |
| US-20170240554-A1 | PESTICIDALLY ACTIVE TETRACYCLIC HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS | SYNGENTA PARTICIPATIONS AG (CH) | 2017-08-24 | — | — | US | disclosed |
| EP-3207044-A1 | PESTICIDALLY ACTIVE TETRACYCLIC HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS | Syngenta Participations AG (CH) | 2017-08-23 | — | — | EP | disclosed |
| WO-2016059145-A1 | PESTICIDALLY ACTIVE TETRACYCLIC HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS | SYNGENTA PARTICIPATIONS AG (CH) | 2016-04-21 | — | — | WO | disclosed |
| WO-2016059145-A1 | PESTICIDALLY ACTIVE TETRACYCLIC HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS | SYNGENTA PARTICIPATIONS AG (CH) | 2016-04-21 | — | — | WO | disclosed |
| US-20070265345-A1 | Novel Biphenyl Compounds And Their Use | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-15 | — | — | US | disclosed |
| EP-1778214-A2 | NOVEL BIPHENYL COMPOUNDS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020358-A2 | NOVEL BIPHENYL COMPOUNDS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2006-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265345-A1 | Novel Biphenyl Compounds And Their Use | KIF5B, KIF5C, KIF5A | KIF11 8/4885CASP1 3378/4885DGAT1 4287/4885 |
| US-10544148-B2 | Pesticidally active tetracyclic heterocyclic derivatives with sulphur containing substituents | DDT, ACHE, TST | KIF11 3660/4885CASP1 224/4885DGAT1 1876/4885 |
| US-20170240554-A1 | PESTICIDALLY ACTIVE TETRACYCLIC HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS | DDT, ACHE, TST | KIF11 3660/4885CASP1 224/4885DGAT1 1876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.