SCHEMBL547148

SCHEMBL547148

O=Cc1c(C=O)c(C=O)c(-c2ccccc2C(=O)O)c(-c2ccccc2)c1C=O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HNF4A P41235 1/20 0.50
MYC P01106 1/20 0.49
KDM4E B2RXH2 3/20 0.46
LMNA P02545 2/20 0.46
POLB P06746 2/20 0.46
FABP3 P05413 2/20 0.42
FABP4 P15090 2/20 0.42
FABP5 Q01469 2/20 0.42
ALDH1A1 P00352 4/20 0.42
ALOX15 P16050 1/20 0.42
ERN1 O75460 1/20 0.42
MAPT P10636 2/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
BCAT2 O15382 1/20 0.41
SOS1 Q07889 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2C9 P11712 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL548482 0.80 LMNA (0.48) LMNAALDH1A1MAPTNPC1RAB9A
SCHEMBL548558 0.79 ALDH1A1 (0.56) HNF4AMYCKDM4ELMNAPOLB
SCHEMBL547716 0.77 FABP4 (0.41) KDM4ELMNAFABP3FABP4FABP5
SCHEMBL5268526 0.77 HNF4A (0.59) HNF4AMYCKDM4ELMNAPOLB
SCHEMBL548159 0.77 HNF4A (0.46) HNF4AFABP3FABP4FABP5ALDH1A1
SCHEMBL11217790 0.75 MYC (0.69) HNF4AMYCKDM4ELMNAPOLB
SCHEMBL548032 0.75 FABP4 (0.41) KDM4ELMNAFABP3FABP4FABP5
SCHEMBL9671555 0.74 MYC (0.58) HNF4AMYCKDM4ELMNAALDH1A1
Benzene SCHEMBL1403559 0.73 HNF4A (0.69) HNF4AMYCKDM4EPOLBFABP3
Benzene SCHEMBL28480917 0.73 HNF4A (0.69) HNF4AMYCKDM4EPOLBFABP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2080750-B1 RADIATION-SENSITIVE COMPOSITION MITSUBISHI GAS CHEMICAL CO (JP) 2020-07-29 EP claimed
EP-2080750-B1 RADIATION-SENSITIVE COMPOSITION MITSUBISHI GAS CHEMICAL CO (JP) 2020-07-29 EP disclosed
US-9897913-B2 Radiation-sensitive composition MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2018-02-20 US disclosed
US-20150030980-A1 RADIATION-SENSITIVE COMPOSITION MITSUBISHI GAS CHEMICAL CO (JP) 2015-01-29 US disclosed
US-8846292-B2 Radiation-sensitive composition MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2014-09-30 US disclosed
US-20120171379-A1 RADIATION-SENSITIVE COMPOSITION MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2012-07-05 US disclosed
US-8110334-B2 Radiation-sensitive composition MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2012-02-07 US disclosed
US-20100047709-A1 RADIATION-SENSITIVE COMPOSITION MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2010-02-25 US disclosed
EP-2080750-A1 RADIATION-SENSITIVE COMPOSITION Mitsubishi Gas Chemical Company, Inc. (JP) 2009-07-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120171379-A1 RADIATION-SENSITIVE COMPOSITION PARG, RAD51, SRMS HNF4A 2396/4885MYC 1800/4885KDM4E 165/4885
US-20100047709-A1 RADIATION-SENSITIVE COMPOSITION C1S, C9, RAD51 HNF4A 2456/4885MYC 2987/4885KDM4E 234/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.