Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.45 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.45 |
| ▸ | APLNR | P35414 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6122171 | 0.89 | ALDH1A1 (0.58) | ALDH1A1HTTSMN1; SMN2TSHRUSP2 | |
| SCHEMBL10824297 | 0.87 | ALDH1A1 (0.62) | ALDH1A1HTTSMN1; SMN2TSHRUSP2 | |
| SCHEMBL10428575 | 0.85 | TSHR (0.49) | ALDH1A1HTTSMN1; SMN2TSHRUSP2 | |
| SCHEMBL24343470 | 0.80 | MEN1 (0.55) | ALDH1A1HTTSMN1; SMN2TSHRUSP2 | |
| SCHEMBL31137817 | 0.79 | LPAR1 (0.51) | ALDH1A1HTTSMN1; SMN2TSHRUSP2 | |
| SCHEMBL6121816 | 0.78 | TSHR (0.73) | ALDH1A1HTTSMN1; SMN2TSHRUSP2 | |
| SCHEMBL17230518 | 0.78 | ALOX5 (0.59) | ALDH1A1TSHRUSP2MEN1KMT2A | |
| SCHEMBL3484433 | 0.78 | TDP1 (0.60) | ALDH1A1HTTSMN1; SMN2TSHRUSP2 | |
| SCHEMBL9416611 | 0.76 | TSPO (0.58) | ALDH1A1HTTSMN1; SMN2TSHRUSP2 | |
| SCHEMBL11806780 | 0.76 | ALDH1A1 (0.56) | ALDH1A1HTTSMN1; SMN2TSHRUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7291622-B2 | Medical uses of carbamate-substituted pyrazolo-pyridine derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2007-11-06 | — | — | US | disclosed |
| US-7291622-B2 | Medical uses of carbamate-substituted pyrazolo-pyridine derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2007-11-06 | — | — | US | disclosed |
| US-7291622-B2 | Medical uses of carbamate-substituted pyrazolo-pyridine derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2007-11-06 | — | — | US | disclosed |
| US-7105523-B2 | Carbamate-substituted pyrazolopyridine-derivatives | BAYER AKTIENGESELISCHAFT (DE) | 2006-09-12 | — | — | US | disclosed |
| US-20050261323-A1 | Medical uses of novel carbamate-substituted pyrazolopyridine derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2005-11-24 | — | — | US | disclosed |
| EP-1339717-B1 | NOVEL CARBAMATE-SUBSTITUTED PYRAZOLOPYRIDINE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2005-02-09 | — | — | EP | disclosed |
| US-20040082596-A1 | Novel carbamate-substituted pyrazolopyridine derivatives | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2004-04-29 | — | — | US | disclosed |
| EP-1339717-A1 | NOVEL CARBAMATE-SUBSTITUTED PYRAZOLOPYRIDINE DERIVATIVES | Bayer Aktiengesellschaft (DE) | 2003-09-03 | — | — | EP | disclosed |
| WO-2002042300-A1 | NOVEL CARBAMATE-SUBSTITUTED PYRAZOLOPYRIDINE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2002-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082596-A1 | Novel carbamate-substituted pyrazolopyridine derivatives | GPR3, NOS3, NPR3 | ALDH1A1 2339/4885HTT 1805/4885SMN1; SMN2 1525/4885 |
| US-20050261323-A1 | Medical uses of novel carbamate-substituted pyrazolopyridine derivatives | NOS3, NOX3, NPR3 | ALDH1A1 1891/4885HTT 4703/4885SMN1; SMN2 2428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.