Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.49 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.49 |
| ▸ | CTSD | P07339 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL615386 | 1.00 | RAB9A (0.57) | RAB9ANPC1ALDH1A1MAPTKCNK3 | |
| SCHEMBL118592 | 0.86 | NPC1 (0.49) | RAB9ANPC1ALDH1A1MAPTKCNK3 | |
| SCHEMBL8591436 | 0.82 | RAB9A (0.51) | RAB9ANPC1ALDH1A1MAPTKCNK3 | |
| SCHEMBL9101 | 0.82 | RAB9A (0.58) | RAB9ANPC1ALDH1A1MAPTKCNK3 | |
| SCHEMBL1603720 | 0.81 | TSHR (0.56) | RAB9ANPC1ALDH1A1MAPTKDM4E | |
| SCHEMBL10873087 | 0.81 | TSHR (0.56) | RAB9ANPC1ALDH1A1MAPTKDM4E | |
| SCHEMBL4019330 | 0.81 | TSHR (0.56) | RAB9ANPC1ALDH1A1MAPTKDM4E | |
| SCHEMBL2036451 | 0.80 | CTSD (0.52) | RAB9ANPC1MAPTKCNK3KCNK9 | |
| SCHEMBL5182345 | 0.79 | ALDH1A1 (0.48) | RAB9ANPC1ALDH1A1MAPTKDM4E | |
| SCHEMBL240091 | 0.78 | RAB9A (0.59) | RAB9ANPC1ALDH1A1MAPTKCNK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7223747-B2 | Halocombstatins and methods of synthesis thereof | ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2007-05-29 | — | — | US | disclosed |
| US-20050176688-A1 | Halocombstatins and methods of synthesis thereof | ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA | 2005-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176688-A1 | Halocombstatins and methods of synthesis thereof | TUBB3, TUBB8B, TUBB8 | RAB9A 1535/4885NPC1 2083/4885ALDH1A1 4790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.