Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Malonic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.64 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.35 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malonic Acid SCHEMBL28033989 | 0.89 | LDHA (0.69) | LDHASRRPOLBFFAR3APEX1 | |
| Propionic Acid SCHEMBL5073547 | 0.83 | FFAR3 (0.67) | LDHASRRPOLBFFAR3CA2 | |
| Glycolic Acid SCHEMBL900919 | 0.83 | LDHA (0.41) | LDHASRRPOLBFFAR3CA2 | |
| Succinic Acid SCHEMBL9695227 | 0.83 | EGLN1 (0.60) | LDHASRRFFAR3APEX1LMNA | |
| Malonic Acid SCHEMBL3608474 | 0.81 | — | — | |
| Malonic Acid SCHEMBL782125 | 0.81 | — | — | |
| Bicarbonate SCHEMBL7692947 | 0.81 | — | — | |
| Malonic Acid SCHEMBL3358611 | 0.80 | — | — | |
| Malonic Acid SCHEMBL1332587 | 0.80 | — | — | |
| Malonic Acid SCHEMBL1332405 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111432811-B | Polymorphs of trimebutine maleate and methods of use thereof | 瓦伦塔有限责任公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-106659657-B | Improved decolorization of dyed keratin fibers | 汉高股份有限及两合公司 | 2021-06-29 | — | — | CN | disclosed |
| CN-111432811-A | Polymorphs of trimebutine maleate and methods of use thereof | 瓦伦塔有限责任公司 | 2020-07-17 | — | — | CN | disclosed |
| US-10456606-B2 | Decolorization of colored keratinic fibers | HENKEL AG & CO. KGAA (DE) | 2019-10-29 | — | — | US | disclosed |
| WO-2019182474-A1 | BUSPIRONE COMBINATIONS FOR TREATING DIZZINESS | Общество с ограниченной ответственностью "ВАЛЕНТА ИНТЕЛЛЕКТ" | 2019-09-26 | — | — | WO | disclosed |
| CN-106470974-B | For treating the compound of virus infection | 韩国巴斯德研究所 | 2019-07-16 | — | — | CN | disclosed |
| CN-106659657-A | Improved decolourization of coloured keratinic fibres | 汉高股份有限及两合公司 | 2017-05-10 | — | — | CN | disclosed |
| US-20170113071-A1 | DECOLORIZATION OF COLORED KERATINIC FIBERS | HENKEL AG & CO. KGAA (DE) | 2017-04-27 | — | — | US | disclosed |
| US-20130101684-A1 | Compounds, Compositions, And Methods For Reducing Or Eliminating Bitter Taste | CHROMOCELL CORPORATION (US) | 2013-04-25 | — | — | US | disclosed |
| WO-2007107008-A1 | COMPOUNDS AND COMPOSITIONS FOR USE IN THE PREVENTION AND TREATMENT OF DISORDERS OF FAT METABOLISM AND OBESITY | INNODIA INC. (CA) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10456606-B2 | Decolorization of colored keratinic fibers | KRT18, TST, ARSA | ADRA1A 2673/4885LDHA 1501/4885SRR 1565/4885 |
| US-20130101684-A1 | Compounds, Compositions, And Methods For Reducing Or Eliminating Bitter Taste | TAS2R5, TAS2R20, TAS2R10 | ADRA1A 3248/4885LDHA 4599/4885SRR 2991/4885 |
| US-20170113071-A1 | DECOLORIZATION OF COLORED KERATINIC FIBERS | KRT18, TST, ARSA | ADRA1A 2673/4885LDHA 1501/4885SRR 1565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.