Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5491596 | 0.82 | ALDH1A1 (0.60) | MAPTPOLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL8512871 | 0.79 | CYP3A4 (0.61) | MAPTKMT2AMEN1ALDH1A1HTT | |
| SCHEMBL20165835 | 0.76 | CYP3A4 (0.57) | MAPTPOLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL8434563 | 0.76 | GRM4 (0.49) | MAPTPOLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL11876081 | 0.75 | SMN1; SMN2 (0.50) | MAPTPOLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL6825635 | 0.74 | L3MBTL1 (0.61) | MAPTKMT2AMEN1ALDH1A1HTT | |
| SCHEMBL11498106 | 0.74 | CYP3A4 (0.71) | MAPTPOLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL27546640 | 0.71 | HPGD (0.61) | MAPTPOLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL5494869 | 0.70 | PKM (0.47) | MAPTKMT2AMEN1THRBALDH1A1 | |
| SCHEMBL4688915 | 0.70 | MEN1 (0.58) | MAPTPOLBKMT2AMEN1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0907363-B1 | Medicament comprising (-)-8-[(4-amino-1-méthylbutyl)amino]-5-(3,4-dichlorophénoxy)-6-méthoxy-4-méthylquinoline for the treatment of parasitic and opportunistic infections | UNIV MISSISSIPPI (US) | 2007-05-23 | — | — | EP | disclosed |
| EP-0907363-A4 | 8-AMINOQUINOLINES | UNIV MISSISSIPPI (US) | 2005-04-06 | — | — | EP | disclosed |
| US-6376511-B2 | ENANTIOMERS OF 8-AMINOQUINOLINE; ANTIPARASITIC COMPOUNDS FOR TREATMENT OR PREVENTION OF PNEUMOCYSTIS CARINII PNEUMONIA, TOXOPLASMOSIS, MALARIA, LEISHMANIASIS, OR TRYPSONOSOMIA | THE UNIVERSITY OF MISSISSIPPI | 2002-04-23 | — | — | US | disclosed |
| US-20010007031-A1 | 8-AMINOQUINOLINES | UNIVERSITY OF MIAMI, THE | 2001-07-05 | — | — | US | disclosed |
| EP-0907363-A1 | 8-AMINOQUINOLINES | THE UNIVERSITY OF MISSISSIPPI (US) | 1999-04-14 | — | — | EP | disclosed |
| WO-1997036590-A1 | 8-AMINOQUINOLINES | THE UNIVERSITY OF MISSISSIPPI (US) | 1997-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010007031-A1 | 8-AMINOQUINOLINES | CYP2C8, COQ8A, TUBA8 | MAPT 3291/4885POLB 998/4885KMT2A 207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.